Increased plasma levels of interleukin-1, interleukin-6 and α-1-antichymotrypsin in patients with Alzheimer's disease: peripheral inflammation or signals from the brain?

Plasma concentrations of interleukin-1β (IL-1β), interleukin-6 (IL-6), C reactive protein (CRP) and α-1-antichymotrypsin (ACT) in 145 patients with probable Alzheimer's disease (AD) and 51 non-demented controls were measured. To investigate the cellular activation of peripheral immune system, p...

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Veröffentlicht in:	Journal of neuroimmunology 2000-02, Vol.103 (1), p.97-102
Hauptverfasser:	Licastro, Federico, Pedrini, Steve, Caputo, Ludovica, Annoni, Giorgio, Davis, Lizabeth Jane, Ferri, Cinzia, Casadei, Valeria, Grimaldi, Luigi Maria Edoardo
Format:	Artikel
Sprache:	eng
Schlagworte:	a1-Antichymotrypsin ACT Aged alpha 1-Antichymotrypsin - blood Alzheimer Disease - blood Alzheimer Disease - immunology Alzheimer's disease Brain - physiology c-Reactive protein Cognitive impairment Female Humans IL-6 Inflammation - complications Interleukin-1 - blood Interleukin-6 - blood Male neopterin Plasma IL-1
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Zusammenfassung:	Plasma concentrations of interleukin-1β (IL-1β), interleukin-6 (IL-6), C reactive protein (CRP) and α-1-antichymotrypsin (ACT) in 145 patients with probable Alzheimer's disease (AD) and 51 non-demented controls were measured. To investigate the cellular activation of peripheral immune system, plasma levels of neopterin were also investigated. Plasma levels of IL-1 were detectable in 17 patients with AD (13%) and only in one control (2%) and average levels of IL-1 were higher in AD patients than in controls ( p
ISSN:	0165-5728 1872-8421
DOI:	10.1016/S0165-5728(99)00226-X