RAP, RAP, open up! New wrinkles for RAP1 in yeast

RAP1 (repressor/activator protein 1) from budding yeast is well known for its involvement in gene activation and repression, telomere structure and function, and replication. Recent studies have examined additional roles for RAP1 in heterochromatin boundary-element formation, creation of hotspots fo...

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Veröffentlicht in:	Trends in genetics 2000-02, Vol.16 (2), p.51-53
1. Verfasser:	Morse, Randall H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromatin Chromatin - physiology Chromatin. Chromosome DNA-binding proteins Fundamental and applied biological sciences. Psychology gene expression genetic recombination genetic regulation Heterochromatin Heterochromatin - physiology meiosis Meiosis - physiology Meiotic recombination Models, Genetic Molecular and cellular biology Molecular genetics RAP1 rap1 GTP-Binding Proteins - genetics rap1 GTP-Binding Proteins - physiology Rap1 protein Recombination, Genetic repressor/activator protein 1 Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - physiology structure Telomere Transcription transcription (genetics) transcription factors
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Zusammenfassung:	RAP1 (repressor/activator protein 1) from budding yeast is well known for its involvement in gene activation and repression, telomere structure and function, and replication. Recent studies have examined additional roles for RAP1 in heterochromatin boundary-element formation, creation of hotspots for meiotic recombination, and chromatin opening. These studies provide new insight into the ability of this abundant DNA-binding protein to participate in a diverse array of functions taking place in a chromatin environment.
ISSN:	0168-9525
DOI:	10.1016/S0168-9525(99)01936-8