Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1

The discovery of a series of phenylalanine derived CCR3 antagonists is reported. Parallel, solution-phase library synthesis has been utilized to delineate the structure–activity relationship leading to the synthesis of highly potent, CCR3-selective antagonists. The discovery of a series of phenylala...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2001-06, Vol.11 (11), p.1441-1444
Hauptverfasser:	Dhanak, Dashyant, Christmann, Lisa T., Darcy, Michael G., Jurewicz, Anthony J., Keenan, Richard M., Lee, Judithann, Sarau, Henry M., Widdowson, Katherine L., White, John R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Humans Medical sciences Pharmacology. Drug treatments Phenylalanine - chemistry Phenylalanine - pharmacology Receptors, CCR3 Receptors, Chemokine - antagonists & inhibitors Receptors, Chemokine - metabolism Structure-Activity Relationship
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Zusammenfassung:	The discovery of a series of phenylalanine derived CCR3 antagonists is reported. Parallel, solution-phase library synthesis has been utilized to delineate the structure–activity relationship leading to the synthesis of highly potent, CCR3-selective antagonists. The discovery of a series of phenylalanine derived CCR3 antagonists is reported. Parallel, solution-phase library synthesis has been utilized to delineate the structure–activity relationship leading to the synthesis of highly potent, CCR3-selective antagonists.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(01)00248-7