Chromogranin A Expression in Hepatocellular Carcinoma in a Patient with Germline MEN1 Gene Mutation

Hepatocellular carcinoma (HCC) was found in a patient with multiple endocrine neoplasia type 1 (MEN 1). The intriguing finding was that the HCC in the patient was positively stained for chromogranin A (CgA), a cellular marker for endocrine and neuroendocrine tumors. The patient had a pancreas endocr...

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Veröffentlicht in:	Internal Medicine 2000, Vol.39(1), pp.20-24
Hauptverfasser:	NAKAJIMA, Koji, SAKURAI, Akihiro, KATAI, Miyuki, YAJIMA, Hiroki, MORI, Jun-ichiro, KATAKURA, Masafumi, TSUCHIYA, Shin-ichi, HASHIZUME, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinoma, Hepatocellular - chemistry Carcinoma, Hepatocellular - complications Chromogranin A Chromogranins - analysis Digestive system Fatal Outcome Germ-Line Mutation glucagonoma Glucagonoma - chemistry Hepatitis C - complications Humans Investigative techniques, diagnostic techniques (general aspects) Liver - chemistry Liver Neoplasms - chemistry Liver Neoplasms - complications Male Medical sciences Middle Aged multiple endocrine neoplasia type 1 Multiple Endocrine Neoplasia Type 1 - complications Multiple Endocrine Neoplasia Type 1 - genetics Neoplasms, Multiple Primary - chemistry Pancreas - chemistry Pancreatic Neoplasms - chemistry Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques type C hepatitis
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Zusammenfassung:	Hepatocellular carcinoma (HCC) was found in a patient with multiple endocrine neoplasia type 1 (MEN 1). The intriguing finding was that the HCC in the patient was positively stained for chromogranin A (CgA), a cellular marker for endocrine and neuroendocrine tumors. The patient had a pancreas endocrine tumor and type C hepatitis, that made pathological diagnosis of the origin of the tumor complicated. (Internal Medicine 39: 20-24, 2000)
ISSN:	0918-2918 1349-7235
DOI:	10.2169/internalmedicine.39.20