Rare polymorphisms in the promoter regions of the human interleukin-12 p35 and interleukin-12 p40 subunit genes

Rare polymorphisms in the promoter regions of the human interleukin-12 p35 and interleukin-12 p40 subunit genes

We have described two rare, single‐nucleotide polymorphisms within the promoter regions of the IL‐12 p35 and p40 subunit genes. Transitions C to T at position −916 from the transcription start of the IL‐12 p35 gene and G to T at position −1287 in the IL‐12 p40 gene were observed.

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Veröffentlicht in:European journal of immunogenetics 2000-02, Vol.27 (1), p.35-36
Hauptverfasser: Pravica, Vera, Brogan, Iain J., Hutchinson, Ian V.
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
Conserved Sequence
Genetic Variation
Humans
Interleukin-12 - genetics
Molecular Sequence Data
p35 protein
p40 protein
Polymorphism, Genetic
Polymorphism, Single-Stranded Conformational
Promoter Regions, Genetic
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Beschreibung
Zusammenfassung:We have described two rare, single‐nucleotide polymorphisms within the promoter regions of the IL‐12 p35 and p40 subunit genes. Transitions C to T at position −916 from the transcription start of the IL‐12 p35 gene and G to T at position −1287 in the IL‐12 p40 gene were observed.
ISSN:0960-7420
1365-2370
DOI:10.1046/j.1365-2370.2000.00190.x