Difficulties with oral platelet glycoprotein IIb/IIIa receptor antagonists

For patients with acute coronary syndromes, compelling data from large-scale trials have established that intravenous GP IIb/IIIa inhibitors decrease likelihood of coronary events when given before and during angioplasty. In these studies, however, the GP IIb/IIIa inhibition did not prevent later ev...

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Veröffentlicht in:	The Lancet (British edition) 2000-01, Vol.355 (9201), p.330-331
Hauptverfasser:	Heeschen, Christopher, Hamm, Christian W
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Angioplasty Aspirin - administration & dosage Cardiovascular disease Clinical trials Death, Sudden, Cardiac - prevention & control Humans Medical research Myocardial Infarction - prevention & control Oximes - administration & dosage Piperidines - administration & dosage Platelet Aggregation Inhibitors - administration & dosage Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Risk Factors
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Beschreibung
Zusammenfassung:	For patients with acute coronary syndromes, compelling data from large-scale trials have established that intravenous GP IIb/IIIa inhibitors decrease likelihood of coronary events when given before and during angioplasty. In these studies, however, the GP IIb/IIIa inhibition did not prevent later events.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(99)00464-X