AIDS onset at high CD4+ cell levels is associated with high HIV load

To identify factors associated with development of AIDS at high CD4+ cell levels a nested case-control study using data from the Multicenter AIDS Cohort Study (MACS) was conducted. HIV-1-infected men who developed AIDS with > or =300/mm3 CD4+ cells (AIDS men) were compared to men who had > or...

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Veröffentlicht in:	AIDS research and human retroviruses 2000-01, Vol.16 (2), p.103-107
Hauptverfasser:	HENNESSEY, K. A, GIORGI, J. V, KAPLAN, A. H, VISSCHER, B. R, GANGE, S, MARGOLICK, J. B, RIDDLER, S, PHAIR, J, DETELS, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired Immunodeficiency Syndrome - pathology Acquired Immunodeficiency Syndrome - virology AIDS/HIV Biological and medical sciences Case-Control Studies CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - pathology Herpes Genitalis - complications HIV-1 - pathogenicity Human viral diseases Humans Infectious diseases Male Medical sciences Multivariate Analysis Neopterin - blood RNA, Viral - analysis Statistics, Nonparametric Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load
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Zusammenfassung:	To identify factors associated with development of AIDS at high CD4+ cell levels a nested case-control study using data from the Multicenter AIDS Cohort Study (MACS) was conducted. HIV-1-infected men who developed AIDS with > or =300/mm3 CD4+ cells (AIDS men) were compared to men who had > or =300/mm3 of CD4+ cells, but remained AIDS free for at least 2 years. The AIDS men had higher plasma HIV-1 RNA levels (mean 10(5.02) vs. 10(4.42), p
ISSN:	0889-2229 1931-8405
DOI:	10.1089/088922200309449