Effect of chronic administration of an aromatase inhibitor to adult male rats on pituitary and testicular function and fertility

The aim of the present study was to evaluate the effects of the administration of a potent non-steroidal aromatase inhibitor, anastrozole, on male reproductive function in adult rats. As anastrozole was to be administered via the drinking water, a preliminary study was undertaken in female rats and...

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Veröffentlicht in:	Journal of endocrinology 2000-02, Vol.164 (2), p.225-238
Hauptverfasser:	Turner, KJ, Morley, M, Atanassova, N, Swanston, ID, Sharpe, RM
Format:	Artikel
Sprache:	eng
Schlagworte:	Anastrozole Animals Biological and medical sciences Copulation - drug effects Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Female Fertility - drug effects Follicle Stimulating Hormone - blood Hormones. Endocrine system Male Medical sciences Nitriles - pharmacology Organ Size Pharmacology. Drug treatments Rats Rats, Wistar Spermatogenesis - drug effects Testis - anatomy & histology Testis - physiology Testosterone - blood Triazoles - pharmacology
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Zusammenfassung:	The aim of the present study was to evaluate the effects of the administration of a potent non-steroidal aromatase inhibitor, anastrozole, on male reproductive function in adult rats. As anastrozole was to be administered via the drinking water, a preliminary study was undertaken in female rats and showed that this route of administration was effective in causing a major decrease in uterine weight (P
ISSN:	0022-0795 1479-6805
DOI:	10.1677/joe.0.1640225