A key role for ICAM-1 in generating effector cells mediating inflammatory responses

We investigated how the accessory molecule interactions encountered during T cell priming influence T cell–mediated destruction of insulin-producing β cells and lead to type 1 diabetes. T cell receptor (TCR)-transgenic CD4 + T cells were primed under controlled conditions in vitro before being adopt...

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Veröffentlicht in:	Nature immunology 2001-06, Vol.2 (6), p.523-529
Hauptverfasser:	Webb, Susan R, Camacho, Stephanie A, Heath, William R, Carbone, Francis R, Sarvetnick, Nora, LeBon, Agnes, Karlsson, Lars, Peterson, Per A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Animals Antigen-Presenting Cells - immunology B7-1 Antigen - metabolism Biomedical and Life Sciences Biomedicine CCL3 protein CCL4 protein CD4-Positive T-Lymphocytes - immunology Diabetes Mellitus, Type 1 - etiology Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Immunology In Vitro Techniques Infectious Diseases Inflammation - etiology Inflammation - immunology Inflammation - pathology Insulin Insulin - genetics intercellular adhesion molecule 1 Intercellular Adhesion Molecule-1 - immunology Lymphocyte Function-Associated Antigen-1 - immunology Lymphocytes Mice Mice, Inbred BALB C Mice, Knockout Mice, Transgenic Pathogens Promoter Regions, Genetic Rats Receptors, Antigen, T-Cell - genetics
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