Haptoglobin phenotype and diabetic nephropathy

To determine if the haptoglobin 2 allele is associated with an increased risk for the development of diabetic nephropathy. This study included 110 consecutive normotensive subjects with Type I (insulin-dependent) diabetes mellitus and Type II (non-insulin-dependent) diabetes mellitus seen in two out...

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Veröffentlicht in:Diabetologia 2001-05, Vol.44 (5), p.602-604
Hauptverfasser: NAKHOUL, F. M, ZOABI, R, KANTER, Y, ZOABI, M, SKORECKI, K, HOCHBERG, I, LEIBU, R, MILLER, B, LEVY, A. P
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Sprache:eng
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Zusammenfassung:To determine if the haptoglobin 2 allele is associated with an increased risk for the development of diabetic nephropathy. This study included 110 consecutive normotensive subjects with Type I (insulin-dependent) diabetes mellitus and Type II (non-insulin-dependent) diabetes mellitus seen in two outpatient clinics in Israel. Diabetes duration was greater than 10 years for Type I diabetes and more than 5 years for Type II diabetic subjects. Microalbuminuria was defined as urinary protein excretion of 30 to 300 mg/24 h, and macroalbuminuria was defined as urinary protein excretion of greater than 300 mg/24 h. Serum was taken from subjects for haptoglobin typing by gel electrophoresis. Of the participating subjects 54 had Type I and 56 had Type II diabetes. None (0/18) of the subjects homozygous for the haptoglobin 1 allele (1-1) showed any sign of diabetic nephropathy, as compared with 34 % (19/55) of subjects homozygous for the haptoglobin 2 allele (2-2) and 27 % (10/37) of heterozygous subjects (2-1) (p < 0.04). Of the subjects 29 showed macroalbuminuria. The risk of developing macroalbuminuria was found to be greater in subjects with two haptoglobin 2 alleles (22 %) (12/55) as compared with one haptoglobin 2 allele (8 %) (3/37) or no haptoglobin 2 alleles (0%) (0/18) (p < 0.03). By showing a graded risk relation to the number of haptoglobin 2 alleles in Type I and Type II diabetic subjects, these studies further support our hypothesis that the haptoglobin phenotype is a major susceptibility gene for the development of diabetic nephropathy.
ISSN:0012-186X
1432-0428
DOI:10.1007/s001250051666