New Lactone-Containing Metabolites from a Marine-Derived Bacterium of the Genus Streptomyces

Six novel metabolites containing a lactone moiety as a common structural feature, along with the previously described (−)-blastmycinolactol, have been isolated from the cultivation broth of a bacterium of the genus Streptomyces isolated from marine sediment. On the basis of the results of combined s...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2001-05, Vol.64 (5), p.664-667
Hauptverfasser:	Cho, Ki Woong, Lee, Hyi-Seung, Rho, Jung-Rae, Kim, Tae Sik, Mo, Sang Jun, Shin, Jongheon
Format:	Artikel
Sprache:	eng
Schlagworte:	3-hydroxy- gamma -butyrolactone 3-hydroxy- gamma -butyrolactones Analytical, structural and metabolic biochemistry Antifungal Agents - chemistry Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Aromatic and heterocyclic compounds Bacteriology Biological and medical sciences blastmycinolactol butenolides Candida albicans - drug effects Fermentation Fundamental and applied biological sciences. Psychology Heterocyclic compounds, pigments lactones Lactones - chemistry Lactones - metabolism Lactones - pharmacology Magnetic Resonance Spectroscopy Marine Marine Biology Microbial Sensitivity Tests Microbiology Morphology, structure, chemical composition natural products Other biological molecules Spectrometry, Mass, Fast Atom Bombardment Streptomyces Streptomyces - metabolism
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Beschreibung
Zusammenfassung:	Six novel metabolites containing a lactone moiety as a common structural feature, along with the previously described (−)-blastmycinolactol, have been isolated from the cultivation broth of a bacterium of the genus Streptomyces isolated from marine sediment. On the basis of the results of combined spectroscopic analysis, the structures of the new compounds have been determined as butenolides and 3-hydroxy-γ-butyrolactones.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np000599g