Upregulation of COX-2 during cardiac allograft rejection

The hypothesis that cyclooxygenase-2 (COX-2) is involved in the myocardial inflammatory response during cardiac allograft rejection was investigated using a rat heterotopic abdominal cardiac transplantation model. COX-2 mRNA and protein in the myocardium of rejecting cardiac allografts were signific...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2000-02, Vol.101 (4), p.430-438
Hauptverfasser:	XIAOCHUN YANG, NINSHENG MA, GREGORY, S, CANNON, P. J, SZABOLCS, M. J, JING ZHONG, ATHAN, E, SCIACCA, R. R, MICHLER, R. E, ANDERSON, G. D, WIESE, J. F, LEAHY, K. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cyclooxygenase 2 Gene Expression Regulation, Enzymologic Graft Rejection - enzymology Graft Rejection - pathology Heart Transplantation - immunology Heart Transplantation - pathology Isoenzymes - genetics Isoenzymes - metabolism Male Medical sciences Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II Prostaglandin-Endoperoxide Synthases - genetics Prostaglandin-Endoperoxide Synthases - metabolism Protein Biosynthesis Rats Rats, Inbred Lew Rats, Inbred WF RNA, Messenger - genetics Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Time Factors Transcription, Genetic Transplantation, Heterotopic Transplantation, Homologous Transplantation, Isogeneic
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Zusammenfassung:	The hypothesis that cyclooxygenase-2 (COX-2) is involved in the myocardial inflammatory response during cardiac allograft rejection was investigated using a rat heterotopic abdominal cardiac transplantation model. COX-2 mRNA and protein in the myocardium of rejecting cardiac allografts were significantly elevated 3 to 5 days after transplantation compared with syngeneic controls (n=3, P
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.CIR.101.4.430