Jumping translocation in acute leukemia of myelomonocytic lineage : a case report and review of the literature

Jumping translocation (JT) is a very rare cytogenetic event, occurring especially in cancer. We describe a case of secondary acute monocytic leukemia (AML5b) with a JT involving the 3q13-3qter segment and leading to a partial trisomy 3. Each clone with JT was associated with trisomy 8 or tetrasomy 8...

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Veröffentlicht in:	Leukemia 2000-01, Vol.14 (1), p.119-122
Hauptverfasser:	BERNARD, M, LEMEE, F, PICARD, F, GHANDOUR, C, DRENOU, B, LE PRISE, P. Y, LAMY, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences chromosome 3 chromosome 8 Female Hematologic and hematopoietic diseases Humans Immunophenotyping In Situ Hybridization, Fluorescence Karyotyping Leukemia, Myelomonocytic, Acute - drug therapy Leukemia, Myelomonocytic, Acute - genetics Leukemia, Myelomonocytic, Acute - immunology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged tetrasomy Translocation, Genetic
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Zusammenfassung:	Jumping translocation (JT) is a very rare cytogenetic event, occurring especially in cancer. We describe a case of secondary acute monocytic leukemia (AML5b) with a JT involving the 3q13-3qter segment and leading to a partial trisomy 3. Each clone with JT was associated with trisomy 8 or tetrasomy 8. The literature of JT in AML cases is reviewed: only 13 cases of AML associated with JT have been previously described, seven of which are AML4/5 FAB subtype. Jumping translocation involvement in leukemogenesis is discussed. Leukemia (2000) 14, 119-122.
ISSN:	0887-6924 1476-5551
DOI:	10.1038/sj.leu.2401637