Low secretion of tumor necrosis factor α, but no other Th1 or Th2 cytokines, by peripheral blood mononuclear cells correlates with chronicity in reactive arthritis

Objective To determine Th1 and Th2 cytokine production in patients with reactive arthritis (ReA) in relation to disease outcome and in comparison with rheumatoid arthritis (RA). Methods Secretion of tumor necrosis factor α (TNFα), interferon‐γ, interleukin‐10 (IL‐10), and IL‐4 by peripheral blood mo...

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Veröffentlicht in:	Arthritis and rheumatism 1999-10, Vol.42 (10), p.2039-2044
Hauptverfasser:	Braun, Jürgen, Yin, Zhinan, Spiller, Inge, Siegert, Stefanie, Rudwaleit, Martin, Liu, Lanzhen, Radbruch, Andreas, Sieper, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV Arthritis, Reactive - blood Arthritis, Reactive - immunology Arthritis, Reactive - physiopathology Biological and medical sciences Biomarkers Chronic Disease Cytokines - immunology Cytokines - secretion Diseases of the osteoarticular system Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Humans Inflammatory joint diseases Male Medical sciences Middle Aged Monocytes - immunology Th1 Cells - immunology Th2 Cells - immunology Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - secretion
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Zusammenfassung:	Objective To determine Th1 and Th2 cytokine production in patients with reactive arthritis (ReA) in relation to disease outcome and in comparison with rheumatoid arthritis (RA). Methods Secretion of tumor necrosis factor α (TNFα), interferon‐γ, interleukin‐10 (IL‐10), and IL‐4 by peripheral blood mononuclear cells (PBMC) from 53 patients with early ReA (disease duration
ISSN:	0004-3591 1529-0131
DOI:	10.1002/1529-0131(199910)42:10<2039::AID-ANR3>3.0.CO;2-6