Immunotherapy of Crohn's Disease

CD4+ T‐lymphocytes have a central role in the pathogenesis of Crohn's disease. The activation and proliferation of T‐lymphocytes following stimulation by antigen‐presenting cells is controlled by regulatory cytokines (i.e. IL‐10) and by induction of programmed cell death. Tissue damage as a res...

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Veröffentlicht in:Scandinavian journal of immunology 2000-01, Vol.51 (1), p.18-22
1. Verfasser: Van Deventer, S J
Format: Artikel
Sprache:eng
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Zusammenfassung:CD4+ T‐lymphocytes have a central role in the pathogenesis of Crohn's disease. The activation and proliferation of T‐lymphocytes following stimulation by antigen‐presenting cells is controlled by regulatory cytokines (i.e. IL‐10) and by induction of programmed cell death. Tissue damage as a result of T‐lymphocyte‐mediated inflammation is mediated by pro‐inflammatory cytokines, including TNF‐α. Novel immunodulatory strategies in Crohn's disease are based on these principles, and it has been demonstrated that neutralization of TNF‐α by administration monoclonal antibodies as well as administration of recombinant human IL‐10 have therapeutic activity in Crohn's disease. The current status of these new therapies as well as future developments are discussed.
ISSN:0300-9475
1365-3083
DOI:10.1046/j.1365-3083.2000.00657.x