New Sesquiterpene Derivatives from the Sponge Dysidea Species with a Selective Inhibitor Profile against Human Phospholipase A2 and Other Leukocyte Functions

Two new sesquiterpene cyclopentenones, dysidenones A and B (2, 3), and a new sesquiterpene aminoquinone, dysidine (4), all containing the same rearranged drimane skeleton, have been isolated from a Dysidea sp. sponge, along with bolinaquinone (1). The structures were established from 2D NMR data. Bo...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2001-05, Vol.64 (5), p.612-615
Hauptverfasser:	Giannini, Clelia, Debitus, Cécile, Lucas, Rut, Ubeda, Amalia, Payá, Miguel, Hooper, John N. A, D'Auria, Maria Valeria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Degranulation - drug effects Cell Survival - drug effects Chromatography, Liquid Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology General pharmacology Humans Leukocyte Elastase - antagonists & inhibitors Leukocytes - drug effects Luminescent Measurements Magnetic Resonance Spectroscopy Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phospholipases A - antagonists & inhibitors Phospholipases A2 Porifera - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Spectrophotometry, Ultraviolet
Online-Zugang:	Volltext
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