Addition of gonadotrophin-releasing hormone agonist and/or two inseminations with husband's sperm do not improve the pregnancy rate in superovulated cycles

Background. A prospective randomized study was performed to evaluate the addition of a gonadotropin releasing hormone agonist (GnRH‐a) during treatment with human menopausal gonadotropins (hMG) in cycles with artificial inseminations with husband's washed sperm (AIH). We also compared the pregnancy rate per cycle after one versus two AIHs. Methods. We designed a 22 factorial trial. A total of 172 couples with unexplained infertility (n=88), endometriosis (n=39), or cervical (n=24) or male (n=21) factors were included, of whom 161 fulfilled the inclusion criteria and treatment. Eighty‐one women were treated with GnRH‐a/hMG and another 80 with hMG only, respectively. Results. The pregnancy rates did not differ between the two stimulation protocols (12% for GnRH‐a/hMG and 9% for hMG). With GnRH‐a/hMG more follicles >15 mm (3.4 and 2.4, respectively; p