Incidence, determinants, and clinical course of reinfarction in-hospital after index acute myocardial infarction (results from the pooled data of the maximal individual therapy in acute myocardial infarction [mitra], and the myocardial infarction registry [MIR])
There are few data about the incidence, determinants, and clinical course of in-hospital repeat acute myocardial infarction (RE-AMI) after an index AMI. From June 1994 to June 1998, 22,613 patients with AMI as an index event were registered by the Maximal Individual Therapy in Acute Myocardial Infar...
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Veröffentlicht in: | The American journal of cardiology 2001-05, Vol.87 (9), p.1039-1044 |
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creator | DÖnges, Klaus Schiele, Rudolf Gitt, Anselm Wienbergen, Harm Schneider, Steffen Zahn, Ralf Grube, Rolf Baumgärtel, Bernd Glunz, Hans-Georg Senges, Jochen |
description | There are few data about the incidence, determinants, and clinical course of in-hospital repeat acute myocardial infarction (RE-AMI) after an index AMI. From June 1994 to June 1998, 22,613 patients with AMI as an index event were registered by the Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) and Myocardial Infarction Registries (MIR). Of these, 1,071 (4.7%) had a RE-AMI. For the index event, 9,143 patients (40.5%) were treated with thrombolysis, 1,707 (7.5%) with primary angioplasty, and 443 (2.0%) with a combination of both. Multivariate analysis showed that previous AMI (odds ratio [OR] 1.59; 95% confidence intervals [CI] 1.35 to 1.86), age >70 years (OR 1.57; 95% CI 1.36 to 1.81), diagnostic first electrocardiogram (OR 1.37; 95% CI 1.19 to 1.59), and female gender (OR 1.14; 95% CI 1.05 to 1.32) were independently associated with a higher incidence of RE-AMI. The incidence of RE-AMI was higher when patients received thrombolysis (OR 1.36; 95% CI 1.15 to 1.61), and it was lower when they underwent primary angioplasty (OR 0.74; 95% CI 0.53 to 1.03) or received β blockers (OR 0.84; 95% CI 0.72 to 0.97). Patients with RE-AMI had higher hospital mortality compared with those without RE-AMI (OR 4.35; 95% CI 3.83 to 4.95). Multivariate logistic regression analysis showed an independent association of RE-AMI with in-hospital death (OR 6.60; 95% CI 5.61 to 7.70), repeat revascularization (OR 2.91; 95% CI 2.42 to 3.50), low workload capacity on the bicycle ergometry test (OR 2.17; 95% CI 1.71 to 2.76), and ejection fraction 70 years, diagnostic first electrocardiogram, and female gender are independent determinants for RE-AMI. Thrombolysis is associated with a higher and β blockers with a lower incidence of RE-AMI. Once a RE-AMI occurs, it is a strong predictor of in-hospital mortality and morbidity. |
doi_str_mv | 10.1016/S0002-9149(01)01458-8 |
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From June 1994 to June 1998, 22,613 patients with AMI as an index event were registered by the Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) and Myocardial Infarction Registries (MIR). Of these, 1,071 (4.7%) had a RE-AMI. For the index event, 9,143 patients (40.5%) were treated with thrombolysis, 1,707 (7.5%) with primary angioplasty, and 443 (2.0%) with a combination of both. Multivariate analysis showed that previous AMI (odds ratio [OR] 1.59; 95% confidence intervals [CI] 1.35 to 1.86), age >70 years (OR 1.57; 95% CI 1.36 to 1.81), diagnostic first electrocardiogram (OR 1.37; 95% CI 1.19 to 1.59), and female gender (OR 1.14; 95% CI 1.05 to 1.32) were independently associated with a higher incidence of RE-AMI. The incidence of RE-AMI was higher when patients received thrombolysis (OR 1.36; 95% CI 1.15 to 1.61), and it was lower when they underwent primary angioplasty (OR 0.74; 95% CI 0.53 to 1.03) or received β blockers (OR 0.84; 95% CI 0.72 to 0.97). Patients with RE-AMI had higher hospital mortality compared with those without RE-AMI (OR 4.35; 95% CI 3.83 to 4.95). Multivariate logistic regression analysis showed an independent association of RE-AMI with in-hospital death (OR 6.60; 95% CI 5.61 to 7.70), repeat revascularization (OR 2.91; 95% CI 2.42 to 3.50), low workload capacity on the bicycle ergometry test (OR 2.17; 95% CI 1.71 to 2.76), and ejection fraction <40% (OR 1.72; 95% CI 1.38 to 2.14) at discharge. Thus, RE-AMI occurs in 4.7% of patients after an AMI. Previous AMI, age >70 years, diagnostic first electrocardiogram, and female gender are independent determinants for RE-AMI. Thrombolysis is associated with a higher and β blockers with a lower incidence of RE-AMI. Once a RE-AMI occurs, it is a strong predictor of in-hospital mortality and morbidity.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/S0002-9149(01)01458-8</identifier><identifier>PMID: 11348599</identifier><identifier>CODEN: AJCDAG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adrenergic beta-Antagonists - therapeutic use ; Adult ; Age Factors ; Aged ; Angioplasty ; Biological and medical sciences ; Cardiology. Vascular system ; Chi-Square Distribution ; Coronary heart disease ; Diabetes Complications ; Electrocardiography ; Female ; Germany - epidemiology ; Heart ; Hospital Mortality ; Humans ; Hypertension - complications ; Incidence ; Logistic Models ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - epidemiology ; Myocardial Infarction - therapy ; Predictive Value of Tests ; Recurrence ; Registries ; Risk Factors ; Sex Factors ; Thrombolytic Therapy</subject><ispartof>The American journal of cardiology, 2001-05, Vol.87 (9), p.1039-1044</ispartof><rights>2001 Excerpta Medica Inc.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-cd676428f97d7c6c88dc1bcccbe48700af1667dc7bd8e5cafbce9f375164b9863</citedby><cites>FETCH-LOGICAL-c455t-cd676428f97d7c6c88dc1bcccbe48700af1667dc7bd8e5cafbce9f375164b9863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9149(01)01458-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=969286$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11348599$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DÖnges, Klaus</creatorcontrib><creatorcontrib>Schiele, Rudolf</creatorcontrib><creatorcontrib>Gitt, Anselm</creatorcontrib><creatorcontrib>Wienbergen, Harm</creatorcontrib><creatorcontrib>Schneider, Steffen</creatorcontrib><creatorcontrib>Zahn, Ralf</creatorcontrib><creatorcontrib>Grube, Rolf</creatorcontrib><creatorcontrib>Baumgärtel, Bernd</creatorcontrib><creatorcontrib>Glunz, Hans-Georg</creatorcontrib><creatorcontrib>Senges, Jochen</creatorcontrib><creatorcontrib>for the Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) and Myocardial Infarction Registry (MIR) Study Groups</creatorcontrib><creatorcontrib>Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) and Myocardial Infarction Registry (MIR) Study Groups</creatorcontrib><title>Incidence, determinants, and clinical course of reinfarction in-hospital after index acute myocardial infarction (results from the pooled data of the maximal individual therapy in acute myocardial infarction [mitra], and the myocardial infarction registry [MIR])</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>There are few data about the incidence, determinants, and clinical course of in-hospital repeat acute myocardial infarction (RE-AMI) after an index AMI. From June 1994 to June 1998, 22,613 patients with AMI as an index event were registered by the Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) and Myocardial Infarction Registries (MIR). Of these, 1,071 (4.7%) had a RE-AMI. For the index event, 9,143 patients (40.5%) were treated with thrombolysis, 1,707 (7.5%) with primary angioplasty, and 443 (2.0%) with a combination of both. Multivariate analysis showed that previous AMI (odds ratio [OR] 1.59; 95% confidence intervals [CI] 1.35 to 1.86), age >70 years (OR 1.57; 95% CI 1.36 to 1.81), diagnostic first electrocardiogram (OR 1.37; 95% CI 1.19 to 1.59), and female gender (OR 1.14; 95% CI 1.05 to 1.32) were independently associated with a higher incidence of RE-AMI. The incidence of RE-AMI was higher when patients received thrombolysis (OR 1.36; 95% CI 1.15 to 1.61), and it was lower when they underwent primary angioplasty (OR 0.74; 95% CI 0.53 to 1.03) or received β blockers (OR 0.84; 95% CI 0.72 to 0.97). Patients with RE-AMI had higher hospital mortality compared with those without RE-AMI (OR 4.35; 95% CI 3.83 to 4.95). Multivariate logistic regression analysis showed an independent association of RE-AMI with in-hospital death (OR 6.60; 95% CI 5.61 to 7.70), repeat revascularization (OR 2.91; 95% CI 2.42 to 3.50), low workload capacity on the bicycle ergometry test (OR 2.17; 95% CI 1.71 to 2.76), and ejection fraction <40% (OR 1.72; 95% CI 1.38 to 2.14) at discharge. Thus, RE-AMI occurs in 4.7% of patients after an AMI. Previous AMI, age >70 years, diagnostic first electrocardiogram, and female gender are independent determinants for RE-AMI. Thrombolysis is associated with a higher and β blockers with a lower incidence of RE-AMI. Once a RE-AMI occurs, it is a strong predictor of in-hospital mortality and morbidity.</description><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Angioplasty</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Chi-Square Distribution</subject><subject>Coronary heart disease</subject><subject>Diabetes Complications</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Heart</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Incidence</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - epidemiology</subject><subject>Myocardial Infarction - therapy</subject><subject>Predictive Value of Tests</subject><subject>Recurrence</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Thrombolytic Therapy</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkltrFTEQx1fx0mP1IygBobTQ1eTsLXkSKV4OVAQvT6WE7GRiI7ubNcmWnm_f7J5D9UH0Kcnk958ZZv5Z9pzRV4yy-vVXSuk6F6wUx5SdUFZWPOf3sxXjjciZYMWDbHWHHGRPQviZnoxV9ePsgLGi5JUQq3uPNgNYjQPgKdEY0fd2UEMMp0QNmkBnBwuqI-AmH5A4QzzawSgP0bqB2CG_cmG0MSHKJHWKaLwhCqaIpN86UF7b9PmH5thjmLoYiPGuJ_EKyehch5poFdVcYQ716sb2i07ba6undE1hr8ZtCv0z_UVvo1eXu_6XVH_FPP6wIfotufi0-XJ58jR7aFQX8Nn-PMy-v3_37exjfv75w-bs7XkOZVXFHHTd1OWaG9HoBmrgXANrAaDFkjeUKsPqutHQtJpjBcq0gMIUTcXqshW8Lg6zo13e0btfE4YoexsAu04N6KYgG8pLUVQsgdUOBO9C8Gjk6NNE_FYyKmcDyMUAct6upEwuBpA86V7sC0xtj_q3ar_xBLzcAyqkzRqvkgHCHSdqsV76fLOjMA3j2qKXAezsEm09QpTa2f80cguU99QW</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>DÖnges, Klaus</creator><creator>Schiele, Rudolf</creator><creator>Gitt, Anselm</creator><creator>Wienbergen, Harm</creator><creator>Schneider, Steffen</creator><creator>Zahn, Ralf</creator><creator>Grube, Rolf</creator><creator>Baumgärtel, Bernd</creator><creator>Glunz, Hans-Georg</creator><creator>Senges, Jochen</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010501</creationdate><title>Incidence, determinants, and clinical course of reinfarction in-hospital after index acute myocardial infarction (results from the pooled data of the maximal individual therapy in acute myocardial infarction [mitra], and the myocardial infarction registry [MIR])</title><author>DÖnges, Klaus ; Schiele, Rudolf ; Gitt, Anselm ; Wienbergen, Harm ; Schneider, Steffen ; Zahn, Ralf ; Grube, Rolf ; Baumgärtel, Bernd ; Glunz, Hans-Georg ; Senges, Jochen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-cd676428f97d7c6c88dc1bcccbe48700af1667dc7bd8e5cafbce9f375164b9863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Angioplasty</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Chi-Square Distribution</topic><topic>Coronary heart disease</topic><topic>Diabetes Complications</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Heart</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Incidence</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - epidemiology</topic><topic>Myocardial Infarction - therapy</topic><topic>Predictive Value of Tests</topic><topic>Recurrence</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Thrombolytic Therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DÖnges, Klaus</creatorcontrib><creatorcontrib>Schiele, Rudolf</creatorcontrib><creatorcontrib>Gitt, Anselm</creatorcontrib><creatorcontrib>Wienbergen, Harm</creatorcontrib><creatorcontrib>Schneider, Steffen</creatorcontrib><creatorcontrib>Zahn, Ralf</creatorcontrib><creatorcontrib>Grube, Rolf</creatorcontrib><creatorcontrib>Baumgärtel, Bernd</creatorcontrib><creatorcontrib>Glunz, Hans-Georg</creatorcontrib><creatorcontrib>Senges, Jochen</creatorcontrib><creatorcontrib>for the Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) and Myocardial Infarction Registry (MIR) Study Groups</creatorcontrib><creatorcontrib>Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) and Myocardial Infarction Registry (MIR) Study Groups</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DÖnges, Klaus</au><au>Schiele, Rudolf</au><au>Gitt, Anselm</au><au>Wienbergen, Harm</au><au>Schneider, Steffen</au><au>Zahn, Ralf</au><au>Grube, Rolf</au><au>Baumgärtel, Bernd</au><au>Glunz, Hans-Georg</au><au>Senges, Jochen</au><aucorp>for the Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) and Myocardial Infarction Registry (MIR) Study Groups</aucorp><aucorp>Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) and Myocardial Infarction Registry (MIR) Study Groups</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence, determinants, and clinical course of reinfarction in-hospital after index acute myocardial infarction (results from the pooled data of the maximal individual therapy in acute myocardial infarction [mitra], and the myocardial infarction registry [MIR])</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>2001-05-01</date><risdate>2001</risdate><volume>87</volume><issue>9</issue><spage>1039</spage><epage>1044</epage><pages>1039-1044</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><coden>AJCDAG</coden><abstract>There are few data about the incidence, determinants, and clinical course of in-hospital repeat acute myocardial infarction (RE-AMI) after an index AMI. From June 1994 to June 1998, 22,613 patients with AMI as an index event were registered by the Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) and Myocardial Infarction Registries (MIR). Of these, 1,071 (4.7%) had a RE-AMI. For the index event, 9,143 patients (40.5%) were treated with thrombolysis, 1,707 (7.5%) with primary angioplasty, and 443 (2.0%) with a combination of both. Multivariate analysis showed that previous AMI (odds ratio [OR] 1.59; 95% confidence intervals [CI] 1.35 to 1.86), age >70 years (OR 1.57; 95% CI 1.36 to 1.81), diagnostic first electrocardiogram (OR 1.37; 95% CI 1.19 to 1.59), and female gender (OR 1.14; 95% CI 1.05 to 1.32) were independently associated with a higher incidence of RE-AMI. The incidence of RE-AMI was higher when patients received thrombolysis (OR 1.36; 95% CI 1.15 to 1.61), and it was lower when they underwent primary angioplasty (OR 0.74; 95% CI 0.53 to 1.03) or received β blockers (OR 0.84; 95% CI 0.72 to 0.97). Patients with RE-AMI had higher hospital mortality compared with those without RE-AMI (OR 4.35; 95% CI 3.83 to 4.95). Multivariate logistic regression analysis showed an independent association of RE-AMI with in-hospital death (OR 6.60; 95% CI 5.61 to 7.70), repeat revascularization (OR 2.91; 95% CI 2.42 to 3.50), low workload capacity on the bicycle ergometry test (OR 2.17; 95% CI 1.71 to 2.76), and ejection fraction <40% (OR 1.72; 95% CI 1.38 to 2.14) at discharge. Thus, RE-AMI occurs in 4.7% of patients after an AMI. Previous AMI, age >70 years, diagnostic first electrocardiogram, and female gender are independent determinants for RE-AMI. Thrombolysis is associated with a higher and β blockers with a lower incidence of RE-AMI. Once a RE-AMI occurs, it is a strong predictor of in-hospital mortality and morbidity.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11348599</pmid><doi>10.1016/S0002-9149(01)01458-8</doi><tpages>6</tpages></addata></record> |
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subjects | Adrenergic beta-Antagonists - therapeutic use Adult Age Factors Aged Angioplasty Biological and medical sciences Cardiology. Vascular system Chi-Square Distribution Coronary heart disease Diabetes Complications Electrocardiography Female Germany - epidemiology Heart Hospital Mortality Humans Hypertension - complications Incidence Logistic Models Male Medical sciences Middle Aged Myocardial Infarction - epidemiology Myocardial Infarction - therapy Predictive Value of Tests Recurrence Registries Risk Factors Sex Factors Thrombolytic Therapy |
title | Incidence, determinants, and clinical course of reinfarction in-hospital after index acute myocardial infarction (results from the pooled data of the maximal individual therapy in acute myocardial infarction [mitra], and the myocardial infarction registry [MIR]) |
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