Developmental changes in prostaglandin E(2) receptor subtypes in porcine ductus arteriosus. Possible contribution in altered responsiveness to prostaglandin E(2)

Prostaglandin E(2) (PGE(2)) is important in ductus arteriosus (DA) patency, but the types of functional PGE(2) receptors (EP) in the developing DA are not known. We postulated that age-dependent alterations in EP and/or their subtypes may possibly contribute to the reduced responsiveness of the newb...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1999-10, Vol.100 (16), p.1751-1756
Hauptverfasser:	Bhattacharya, M, Asselin, P, Hardy, P, Guerguerian, A M, Shichi, H, Hou, X, Varma, D R, Bouayad, A, Fouron, J C, Clyman, R I, Chemtob, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Binding, Competitive Cyclic AMP - metabolism Dinoprostone - analogs & derivatives Dinoprostone - metabolism Dinoprostone - pharmacology Ductus Arteriosus - embryology Ductus Arteriosus - physiology Embryonic and Fetal Development - physiology Gestational Age Kinetics Radioligand Assay Receptors, Prostaglandin E - classification Receptors, Prostaglandin E - metabolism Signal Transduction - drug effects Swine Tritium Vascular Patency
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Zusammenfassung:	Prostaglandin E(2) (PGE(2)) is important in ductus arteriosus (DA) patency, but the types of functional PGE(2) receptors (EP) in the developing DA are not known. We postulated that age-dependent alterations in EP and/or their subtypes may possibly contribute to the reduced responsiveness of the newborn DA to PGE(2). We determined PGE(2) receptor subtypes by competition binding and immunoblot studies on the DA of fetal ( approximately 75% and 90% gestation) and newborn (
ISSN:	1524-4539