Cardiac effects of hexarelin in hypopituitary adults

Cardiac effects of hexarelin in hypopituitary adults

Growth hormone (GH)-releasing peptides possess specific pituitary, hypothalamic, and myocardial receptors. Seven adult male patients with GH deficiency (GHD) (age, mean±S.E.M.: 42.0±4.0 year) were studied by equilibrium radionuclide angiocardiography after i.v. administration of hexarelin, a peptide...

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Veröffentlicht in:European journal of pharmacology 1999-09, Vol.381 (1), p.31-38
Hauptverfasser: Bisi, Gianni, Podio, Valerio, Valetto, Maria Rosa, Broglio, Fabio, Bertuccio, Giovanni, Aimaretti, Gianluca, Pelosi, Ettore, Del Rio, Graziano, Muccioli, Giampiero, Ong, Hui, Boghen, Muni Franklin, Deghenghi, Romano, Ghigo, Ezio
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Flushing - chemically induced
Growth hormone (GH) secretagogue
Growth hormone deficiency (GHD), adult
Haemodynamic
Heart - drug effects
Heart - physiopathology
Hemodynamics - drug effects
Hexarelin
Hormones. Endocrine system
Human Growth Hormone - blood
Human Growth Hormone - deficiency
Human Growth Hormone - drug effects
Humans
Hypopituitarism - diagnostic imaging
Hypopituitarism - physiopathology
Insulin-Like Growth Factor I - drug effects
Insulin-Like Growth Factor I - metabolism
Male
Medical sciences
Middle Aged
Oligopeptides - adverse effects
Oligopeptides - pharmacology
Pharmacology. Drug treatments
Radionuclide Angiography
Radionuclide imaging
Ventricular function, left
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Zusammenfassung:Growth hormone (GH)-releasing peptides possess specific pituitary, hypothalamic, and myocardial receptors. Seven adult male patients with GH deficiency (GHD) (age, mean±S.E.M.: 42.0±4.0 year) were studied by equilibrium radionuclide angiocardiography after i.v. administration of hexarelin, a peptide GH secretagogue. Data for these patients were compared with those for nine adult male controls (37.0±2.7 year). The GH response to hexarelin was negligible in patients with GHD compared to control subjects (CS) (peak: 1.9±0.9 vs. 45.7±3.6 μg/l, P
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(99)00537-3