Role of P-glycoprotein-mediated secretion in absorptive drug permeability : An approach using passive membrane permeability and affinity to P-glycoprotein

It has been shown in vivo and in vitro that P-glycoprotein (P-gp) may be able to influence the permeability of its substrates across biological membranes. However, the quantitative contribution of the secretion process mediated by P-gp on the overall permeability of membranes has not been determined...

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