A Novel Enantioselective Synthetic Route to Omuralide Analogues with the Potential for Species Selectivity in Proteasome Inhibition

The building blocks shown can be combined for an enantioselective construction of the simplified omuralide analogue 4 in nine steps, with the use of (R)-atrolactic acid as a recoverable chiral controller.

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Bibliographische Detailangaben
Veröffentlicht in:	Organic letters 2001-05, Vol.3 (9), p.1395-1397
Hauptverfasser:	Crane, Sheldon N, Corey, E. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - analogs & derivatives Acetylcysteine - chemistry Catalysis Cysteine Endopeptidases - chemistry Glycine - chemistry Lactates - chemistry Lactones - chemical synthesis Lactones - chemistry Molecular Structure Multienzyme Complexes - antagonists & inhibitors Multienzyme Complexes - chemistry Proteasome Endopeptidase Complex Stereoisomerism Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	The building blocks shown can be combined for an enantioselective construction of the simplified omuralide analogue 4 in nine steps, with the use of (R)-atrolactic acid as a recoverable chiral controller.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol015757p