Polar Production of Interleukin-8 by Mesothelial Cells Promotes the Transmesothelial Migration of Neutrophils: Role of Intercellular Adhesion Molecule–1

Polar Production of Interleukin-8 by Mesothelial Cells Promotes the Transmesothelial Migration of Neutrophils: Role of Intercellular Adhesion Molecule–1

Migration of polymorphonuclear neutrophils (PMNL) from the vascular compartment into the pleural space occurs rapidly during the development of parapneumonic effusions. This study investigated the polarized secretion of interleukin (IL)–8 in activated pleural mesothelial cells (PMC) and the migratio...

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Veröffentlicht in:The Journal of infectious diseases 2001-06, Vol.183 (11), p.1638-1645
Hauptverfasser: Nasreen, Najmunnisa, Mohammed, Kamal A., Hardwick, Joyce, Van Horn, Robert D., Sanders, Kerry L., Doerschuk, C. M., Hott, Jeff W., Antony, Veena B.
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies
Bacteriology
Biological and medical sciences
Cell Movement
Cells, Cultured
Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges
Chemokines
Chemotaxis
Cultured cells
Epithelial cells
Epithelial Cells - immunology
Epithelial Cells - microbiology
Epithelium
Epithelium - immunology
Flow Cytometry
Fundamental and applied biological sciences. Psychology
Humans
In Situ Hybridization
In Vitro Techniques
Intercellular Adhesion Molecule-1 - analysis
Intercellular Adhesion Molecule-1 - physiology
Interleukin-8 - analysis
Interleukin-8 - pharmacology
Isotypes
Leukocytes, Mononuclear
Major Articles
Microbiology
Neutrophils
Neutrophils - drug effects
Neutrophils - immunology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Pleura - cytology
Polycarbonates
Staphylococcus aureus
Transmigration
Vertebrates: nervous system and sense organs
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Zusammenfassung:Migration of polymorphonuclear neutrophils (PMNL) from the vascular compartment into the pleural space occurs rapidly during the development of parapneumonic effusions. This study investigated the polarized secretion of interleukin (IL)–8 in activated pleural mesothelial cells (PMC) and the migration of PMNL across resting, activated PMC monolayers. Results show that PMC produce IL-8 in a polar manner. When PMC were stimulated with Staphylococcus aureus or IL-1β at the basal or at the apical surface, significantly (P
ISSN:0022-1899
1537-6613
DOI:10.1086/320700