Dehydrophenylalanine analogues: conformational characterization

Few dehydrophenylalanine (ΔPhe) analogues (X-ΔPhe-Phe-Gly-X1, X=Ac-; Boc-; Z-; X1=OMe; OH; ONH 2) of virus replication inhibiting peptide (Z-D-Phe-Phe-Gly) were synthesized, and their solution conformations were investigated by 1H NMR, UV and circular dichroism (CD) spectroscopy. Homogeneity of thes...

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Veröffentlicht in:	International journal of biological macromolecules 1999-10, Vol.26 (1), p.17-21
1. Verfasser:	Siddiqui, Mahtab Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Circular Dichroism Circular dichroism spectroscopy Conformation Dehydrophenylalanine peptides Magnetic Resonance Spectroscopy Models, Molecular Molecular Conformation Oligopeptides - chemistry Peptides - chemical synthesis Peptides - isolation & purification Phenylalanine - analogs & derivatives Phenylalanine - chemistry Spectrophotometry, Ultraviolet Synthesis
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Zusammenfassung:	Few dehydrophenylalanine (ΔPhe) analogues (X-ΔPhe-Phe-Gly-X1, X=Ac-; Boc-; Z-; X1=OMe; OH; ONH 2) of virus replication inhibiting peptide (Z-D-Phe-Phe-Gly) were synthesized, and their solution conformations were investigated by 1H NMR, UV and circular dichroism (CD) spectroscopy. Homogeneity of these analogues was also assessed by reverse phase-high performance liquid chromatography (RP-HPLC) using water–acetonitrile gradients.
ISSN:	0141-8130 1879-0003
DOI:	10.1016/S0141-8130(99)00063-X