The airway longitudinal elastic fiber network and mucosal folding in patients with asthma
A submucosal network of elastic fibers in a collagen and myofibroblast matrix form discrete longitudinal bundles (LB) in the bronchial tree. The LB may affect airway function by altering the mechanical properties of the airway wall or by changing the folding behavior of the airway mucosa. The area a...
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Veröffentlicht in: | American journal of respiratory and critical care medicine 2000, Vol.161 (1), p.244-248 |
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creator | CARROLL, N. G PERRY, S KARKHANIS, A HARJI, S BUTT, J JAMES, A. L GREEN, F. H. Y |
description | A submucosal network of elastic fibers in a collagen and myofibroblast matrix form discrete longitudinal bundles (LB) in the bronchial tree. The LB may affect airway function by altering the mechanical properties of the airway wall or by changing the folding behavior of the airway mucosa. The area and number of LB were quantified from 12 cases each of fatal asthma (FA), nonfatal asthma (NF), and nonasthmatic (NA) control cases on elastic-trichrome stained airways. The effects of group, sex, age, and smoking were examined using multiple linear regression. The area fraction of LB increased (p < 0.05) approximately twofold in cases of FA compared with NA control cases in both large and small airways. The areas of LB were increased in smokers, older subjects, and men (p < 0.05). The number of mucosal folds was related to the number of longitudinal bundles in asthmatics and nonasthmatics and was not different between groups. Collagen and myofibroblasts were increased (p < 0.05) in LB of FA and NF cases compared with NA control cases. The increased size and altered composition of LB in asthma may influence airway function; however, excessive airway narrowing in asthma is not due to altered numbers of mucosal folds. |
doi_str_mv | 10.1164/ajrccm.161.1.9805005 |
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G ; PERRY, S ; KARKHANIS, A ; HARJI, S ; BUTT, J ; JAMES, A. L ; GREEN, F. H. Y</creator><creatorcontrib>CARROLL, N. G ; PERRY, S ; KARKHANIS, A ; HARJI, S ; BUTT, J ; JAMES, A. L ; GREEN, F. H. Y</creatorcontrib><description>A submucosal network of elastic fibers in a collagen and myofibroblast matrix form discrete longitudinal bundles (LB) in the bronchial tree. The LB may affect airway function by altering the mechanical properties of the airway wall or by changing the folding behavior of the airway mucosa. The area and number of LB were quantified from 12 cases each of fatal asthma (FA), nonfatal asthma (NF), and nonasthmatic (NA) control cases on elastic-trichrome stained airways. The effects of group, sex, age, and smoking were examined using multiple linear regression. The area fraction of LB increased (p < 0.05) approximately twofold in cases of FA compared with NA control cases in both large and small airways. The areas of LB were increased in smokers, older subjects, and men (p < 0.05). The number of mucosal folds was related to the number of longitudinal bundles in asthmatics and nonasthmatics and was not different between groups. Collagen and myofibroblasts were increased (p < 0.05) in LB of FA and NF cases compared with NA control cases. The increased size and altered composition of LB in asthma may influence airway function; however, excessive airway narrowing in asthma is not due to altered numbers of mucosal folds.</description><identifier>ISSN: 1073-449X</identifier><identifier>EISSN: 1535-4970</identifier><identifier>DOI: 10.1164/ajrccm.161.1.9805005</identifier><identifier>PMID: 10619827</identifier><language>eng</language><publisher>New York, NY: American Lung Association</publisher><subject>Adult ; Asthma - metabolism ; Asthma - pathology ; Biological and medical sciences ; Bronchi - metabolism ; Bronchi - pathology ; Collagen - metabolism ; Elastic Tissue - pathology ; Female ; Fibroblasts - metabolism ; Fibroblasts - pathology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Mucous Membrane - metabolism ; Mucous Membrane - pathology ; Pathology. Cytology. Biochemistry. Spectrometry. 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G</creatorcontrib><creatorcontrib>PERRY, S</creatorcontrib><creatorcontrib>KARKHANIS, A</creatorcontrib><creatorcontrib>HARJI, S</creatorcontrib><creatorcontrib>BUTT, J</creatorcontrib><creatorcontrib>JAMES, A. L</creatorcontrib><creatorcontrib>GREEN, F. H. Y</creatorcontrib><title>The airway longitudinal elastic fiber network and mucosal folding in patients with asthma</title><title>American journal of respiratory and critical care medicine</title><addtitle>Am J Respir Crit Care Med</addtitle><description>A submucosal network of elastic fibers in a collagen and myofibroblast matrix form discrete longitudinal bundles (LB) in the bronchial tree. The LB may affect airway function by altering the mechanical properties of the airway wall or by changing the folding behavior of the airway mucosa. The area and number of LB were quantified from 12 cases each of fatal asthma (FA), nonfatal asthma (NF), and nonasthmatic (NA) control cases on elastic-trichrome stained airways. The effects of group, sex, age, and smoking were examined using multiple linear regression. The area fraction of LB increased (p < 0.05) approximately twofold in cases of FA compared with NA control cases in both large and small airways. The areas of LB were increased in smokers, older subjects, and men (p < 0.05). The number of mucosal folds was related to the number of longitudinal bundles in asthmatics and nonasthmatics and was not different between groups. Collagen and myofibroblasts were increased (p < 0.05) in LB of FA and NF cases compared with NA control cases. The increased size and altered composition of LB in asthma may influence airway function; however, excessive airway narrowing in asthma is not due to altered numbers of mucosal folds.</description><subject>Adult</subject><subject>Asthma - metabolism</subject><subject>Asthma - pathology</subject><subject>Biological and medical sciences</subject><subject>Bronchi - metabolism</subject><subject>Bronchi - pathology</subject><subject>Collagen - metabolism</subject><subject>Elastic Tissue - pathology</subject><subject>Female</subject><subject>Fibroblasts - metabolism</subject><subject>Fibroblasts - pathology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mucous Membrane - metabolism</subject><subject>Mucous Membrane - pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Respiratory system</subject><subject>Smoking - metabolism</subject><subject>Smoking - pathology</subject><issn>1073-449X</issn><issn>1535-4970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtKAzEUhoMoWqtvIJKFuJuazOS6lOINCm4q6CqcyWTa6FxqMkPp2xtpQVfnLL7_55wPoStKZpQKdgefwdp2RgWd0ZlWhBPCj9CE8oJnTEtynHYii4wx_X6GzmP8JITmipJTdEaJoFrlcoI-lmuHwYct7HDTdys_jJXvoMGugTh4i2tfuoA7N2z78IWhq3A72j4mou6bhK6w7_AGBu-6IeKtH9Y4BdctXKCTGproLg9zit4eH5bz52zx-vQyv19ktijyIdMUJBElr50qiJU5hzJdKSwoVnMmRKmIsLxUipU6vWIrWUlbaMspA6CaFVN0u-_dhP57dHEwrY_WNQ10rh-jkSQ9KjVPINuDNvQxBlebTfAthJ2hxPwqNXulJik11ByUptj1oX8sW1f9C-0dJuDmAEC00NQBOuvjH5czQaQqfgD8r4Dr</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>CARROLL, N. 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Miscellaneous investigative techniques</topic><topic>Respiratory system</topic><topic>Smoking - metabolism</topic><topic>Smoking - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CARROLL, N. G</creatorcontrib><creatorcontrib>PERRY, S</creatorcontrib><creatorcontrib>KARKHANIS, A</creatorcontrib><creatorcontrib>HARJI, S</creatorcontrib><creatorcontrib>BUTT, J</creatorcontrib><creatorcontrib>JAMES, A. L</creatorcontrib><creatorcontrib>GREEN, F. H. 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The effects of group, sex, age, and smoking were examined using multiple linear regression. The area fraction of LB increased (p < 0.05) approximately twofold in cases of FA compared with NA control cases in both large and small airways. The areas of LB were increased in smokers, older subjects, and men (p < 0.05). The number of mucosal folds was related to the number of longitudinal bundles in asthmatics and nonasthmatics and was not different between groups. Collagen and myofibroblasts were increased (p < 0.05) in LB of FA and NF cases compared with NA control cases. The increased size and altered composition of LB in asthma may influence airway function; however, excessive airway narrowing in asthma is not due to altered numbers of mucosal folds.</abstract><cop>New York, NY</cop><pub>American Lung Association</pub><pmid>10619827</pmid><doi>10.1164/ajrccm.161.1.9805005</doi><tpages>5</tpages></addata></record> |
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source | MEDLINE; American Thoracic Society (ATS) Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
subjects | Adult Asthma - metabolism Asthma - pathology Biological and medical sciences Bronchi - metabolism Bronchi - pathology Collagen - metabolism Elastic Tissue - pathology Female Fibroblasts - metabolism Fibroblasts - pathology Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Mucous Membrane - metabolism Mucous Membrane - pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Respiratory system Smoking - metabolism Smoking - pathology |
title | The airway longitudinal elastic fiber network and mucosal folding in patients with asthma |
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