A direct method for the formation of peptide and carbohydrate dendrimers

Two new methods for the modification of PAMAM dendrimers have been developed which allow the covergent synthesis of either peptide or carbohydrate-bearing dendrimer molecules. Both methods involve condensation between hydroxylamino nucleophiles and appropriate carbonyl-bearing reaction partners. Two...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 1999-10, Vol.9 (19), p.2785-2788
Hauptverfasser:	Mitchell, Jeffrey P., Roberts, Kade D., Langley, Jane, Koentgen, Frank, Lambert, John N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbohydrates - chemistry Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides Carbohydrates. Nucleosides and nucleotides Chemistry Chromatography, Gel Electrophoresis, Polyacrylamide Gel Exact sciences and technology Glycoconjugates - chemistry Molecular Sequence Data Molecular Structure Organic chemistry Peptides Peptides - chemistry Polyamines - chemistry Polymers - chemistry Preparations and properties
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Beschreibung
Zusammenfassung:	Two new methods for the modification of PAMAM dendrimers have been developed which allow the covergent synthesis of either peptide or carbohydrate-bearing dendrimer molecules. Both methods involve condensation between hydroxylamino nucleophiles and appropriate carbonyl-bearing reaction partners. Two new methods for the modification of PAMAM dendrimers allowing short syntheses of either peptide-or carbohydrate-bearing PAMAM dendrimers. Both methods involve condensation between hydroxylamino nucleophiles and carbonyl-bearing reaction partners.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/S0960-894X(99)00480-1