Predicting the Status of the Nonsentinel Axillary Nodes: A Multicenter Study

BACKGROUND Sentinel lymph node (SLN) biopsy is a minimally invasive procedure that provides accurate nodal staging information. The need for completion axillary dissection after finding a positive SLN for breast cancer has been questioned. HYPOTHESIS The presence of nonsentinel node (NSN) metastases...

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Veröffentlicht in:Archives of surgery (Chicago. 1960) 2001-05, Vol.136 (5), p.563-568
Hauptverfasser: Wong, Sandra L, Edwards, Michael J, Chao, Celia, Tuttle, Todd M, Noyes, R. Dirk, Woo, Claudine, Cerrito, Patricia B, McMasters, Kelly M
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Sprache:eng
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Zusammenfassung:BACKGROUND Sentinel lymph node (SLN) biopsy is a minimally invasive procedure that provides accurate nodal staging information. The need for completion axillary dissection after finding a positive SLN for breast cancer has been questioned. HYPOTHESIS The presence of nonsentinel node (NSN) metastases in the axillary dissection specimen correlates with tumor size, the number of SLNs removed, and the number of positive SLNs. DESIGN Prospective, multi-institutional study. PARTICIPANTS AND METHODS The University of Louisville Breast Cancer Sentinel Lymph Node Study is a nationwide study involving 148 surgeons. All patients underwent SLN biopsy, followed by level I/II axillary dissection. All SLNs were evaluated histologically at a minimum of 2-mm intervals. Immunohistochemical analysis using antibodies for cytokeratin was performed at the discretion of each participating institution. All NSNs were evaluated by routine histologic examination. RESULTS An SLN was identified in 1268 (90%) of 1415 patients. Increasing tumor size was significantly correlated with increasing likelihood of positive NSNs: T1a, 14%; T1b, 22%; T1c, 30%; T2, 45%; and T3, 57% (P = .002, χ2 test). The presence of positive NSNs was not significantly associated with the number of SLNs removed. Patients with more than 1 positive SLN were more likely to have positive NSNs than those with only 1 positive SLN (50% vs 32%; P
ISSN:0004-0010
2168-6254
1538-3644
2168-6262
DOI:10.1001/archsurg.136.5.563