Differential Activation of Cytokine Secretion in Primary Human Colonic Fibroblast/Myofibroblast Cultures
Background: Fibroblasts and myofibroblasts are known to secrete a wide spectrum of cytokines, but the individual spectrum is tissue-specific. We investigated the effect of cell activation on cytokine secretion of isolated human colonic fibroblasts/myofibroblasts from control patients and patients wi...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 2001-01, Vol.36 (4), p.389-398 |
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| container_end_page | 398 |
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| container_issue | 4 |
| container_start_page | 389 |
| container_title | Scandinavian journal of gastroenterology |
| container_volume | 36 |
| creator | ROGLER, G GELBMANN, C. M VOGL, D BRUNNER, M SCHÖLMERICH, J FALK, W ANDUS, T BRAND, K |
| description | Background: Fibroblasts and myofibroblasts are known to secrete a wide spectrum of cytokines, but the individual spectrum is tissue-specific. We investigated the effect of cell activation on cytokine secretion of isolated human colonic fibroblasts/myofibroblasts from control patients and patients with mucosal inflammation. Methods: |
| doi_str_mv | 10.1080/00365520119240 |
| format | Article |
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Methods:</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/00365520119240</identifier><identifier>PMID: 11336164</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Informa UK Ltd</publisher><subject>Adult ; Analysis of Variance ; Biological and medical sciences ; Biopsy, Needle ; Cells, Cultured ; Colitis, Ulcerative - metabolism ; Colitis, Ulcerative - pathology ; Colon - metabolism ; Crohn Disease - pathology ; Cytokines - analysis ; Cytokines - drug effects ; Cytokines - metabolism ; Electrophoresis ; Enzyme-Linked Immunosorbent Assay ; Female ; Fibroblasts - drug effects ; Fibroblasts - metabolism ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Ibd Myofibroblasts Nf-KB Il-8 Il-6 ; Immunohistochemistry ; Interleukin-1 - pharmacology ; Interleukin-10 - pharmacology ; Intestinal Mucosa - cytology ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - metabolism ; Lipopolysaccharides - pharmacology ; Male ; Medical sciences ; Middle Aged ; NF-kappa B - drug effects ; NF-kappa B - metabolism ; Other diseases. Semiology ; Probability ; Reference Values ; Sensitivity and Specificity ; Stomach. Duodenum. Small intestine. Colon. Rectum. 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M</creatorcontrib><creatorcontrib>VOGL, D</creatorcontrib><creatorcontrib>BRUNNER, M</creatorcontrib><creatorcontrib>SCHÖLMERICH, J</creatorcontrib><creatorcontrib>FALK, W</creatorcontrib><creatorcontrib>ANDUS, T</creatorcontrib><creatorcontrib>BRAND, K</creatorcontrib><title>Differential Activation of Cytokine Secretion in Primary Human Colonic Fibroblast/Myofibroblast Cultures</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Background: Fibroblasts and myofibroblasts are known to secrete a wide spectrum of cytokines, but the individual spectrum is tissue-specific. We investigated the effect of cell activation on cytokine secretion of isolated human colonic fibroblasts/myofibroblasts from control patients and patients with mucosal inflammation. Methods:</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Cells, Cultured</subject><subject>Colitis, Ulcerative - metabolism</subject><subject>Colitis, Ulcerative - pathology</subject><subject>Colon - metabolism</subject><subject>Crohn Disease - pathology</subject><subject>Cytokines - analysis</subject><subject>Cytokines - drug effects</subject><subject>Cytokines - metabolism</subject><subject>Electrophoresis</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fibroblasts - drug effects</subject><subject>Fibroblasts - metabolism</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Ibd Myofibroblasts Nf-KB Il-8 Il-6</subject><subject>Immunohistochemistry</subject><subject>Interleukin-1 - pharmacology</subject><subject>Interleukin-10 - pharmacology</subject><subject>Intestinal Mucosa - cytology</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>NF-kappa B - drug effects</subject><subject>NF-kappa B - metabolism</subject><subject>Other diseases. Semiology</subject><subject>Probability</subject><subject>Reference Values</subject><subject>Sensitivity and Specificity</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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M ; VOGL, D ; BRUNNER, M ; SCHÖLMERICH, J ; FALK, W ; ANDUS, T ; BRAND, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2654-356eefde2886eaec7e69684f969c17cbe2d890b686f2bcbdfab3de63f829406a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Cells, Cultured</topic><topic>Colitis, Ulcerative - metabolism</topic><topic>Colitis, Ulcerative - pathology</topic><topic>Colon - metabolism</topic><topic>Crohn Disease - pathology</topic><topic>Cytokines - analysis</topic><topic>Cytokines - drug effects</topic><topic>Cytokines - metabolism</topic><topic>Electrophoresis</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fibroblasts - drug effects</topic><topic>Fibroblasts - metabolism</topic><topic>Gastroenterology. Liver. 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| fulltext | fulltext |
| identifier | ISSN: 0036-5521 |
| ispartof | Scandinavian journal of gastroenterology, 2001-01, Vol.36 (4), p.389-398 |
| issn | 0036-5521 1502-7708 |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Adult Analysis of Variance Biological and medical sciences Biopsy, Needle Cells, Cultured Colitis, Ulcerative - metabolism Colitis, Ulcerative - pathology Colon - metabolism Crohn Disease - pathology Cytokines - analysis Cytokines - drug effects Cytokines - metabolism Electrophoresis Enzyme-Linked Immunosorbent Assay Female Fibroblasts - drug effects Fibroblasts - metabolism Gastroenterology. Liver. Pancreas. Abdomen Humans Ibd Myofibroblasts Nf-KB Il-8 Il-6 Immunohistochemistry Interleukin-1 - pharmacology Interleukin-10 - pharmacology Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Lipopolysaccharides - pharmacology Male Medical sciences Middle Aged NF-kappa B - drug effects NF-kappa B - metabolism Other diseases. Semiology Probability Reference Values Sensitivity and Specificity Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumor Necrosis Factor-alpha - pharmacology |
| title | Differential Activation of Cytokine Secretion in Primary Human Colonic Fibroblast/Myofibroblast Cultures |
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