Differential Activation of Cytokine Secretion in Primary Human Colonic Fibroblast/Myofibroblast Cultures

Background: Fibroblasts and myofibroblasts are known to secrete a wide spectrum of cytokines, but the individual spectrum is tissue-specific. We investigated the effect of cell activation on cytokine secretion of isolated human colonic fibroblasts/myofibroblasts from control patients and patients wi...

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Veröffentlicht in:	Scandinavian journal of gastroenterology 2001-01, Vol.36 (4), p.389-398
Hauptverfasser:	ROGLER, G, GELBMANN, C. M, VOGL, D, BRUNNER, M, SCHÖLMERICH, J, FALK, W, ANDUS, T, BRAND, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Biological and medical sciences Biopsy, Needle Cells, Cultured Colitis, Ulcerative - metabolism Colitis, Ulcerative - pathology Colon - metabolism Crohn Disease - pathology Cytokines - analysis Cytokines - drug effects Cytokines - metabolism Electrophoresis Enzyme-Linked Immunosorbent Assay Female Fibroblasts - drug effects Fibroblasts - metabolism Gastroenterology. Liver. Pancreas. Abdomen Humans Ibd Myofibroblasts Nf-KB Il-8 Il-6 Immunohistochemistry Interleukin-1 - pharmacology Interleukin-10 - pharmacology Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Lipopolysaccharides - pharmacology Male Medical sciences Middle Aged NF-kappa B - drug effects NF-kappa B - metabolism Other diseases. Semiology Probability Reference Values Sensitivity and Specificity Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumor Necrosis Factor-alpha - pharmacology
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Zusammenfassung:	Background: Fibroblasts and myofibroblasts are known to secrete a wide spectrum of cytokines, but the individual spectrum is tissue-specific. We investigated the effect of cell activation on cytokine secretion of isolated human colonic fibroblasts/myofibroblasts from control patients and patients with mucosal inflammation. Methods:
ISSN:	0036-5521 1502-7708
DOI:	10.1080/00365520119240