New Taxane Analogues from the Needles of Taxus canadensis

Eight minor taxanes have been identified for the first time in Taxus canadensis needles. Four of these metabolites are new taxane analogues: 7-acetyl-10-deacetyltaxol (1), 2‘-acetyl-7-epi-cephalomannine (2), 10-deacetyl-10-oxo-7-epi-cephalomannine (3), and 10-acetylglycollylbaccatin VI (4).

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2001-04, Vol.64 (4), p.450-455
Hauptverfasser:	Zhang, Junzeng, Sauriol, Francoise, Mamer, Orval, You, Xiao-Li, Alaoui-Jamali, Moulay A, Batist, Gerald, Zamir, Lolita O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - pathology Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Biological and medical sciences Breast Neoplasms - pathology Drug Screening Assays, Antitumor General pharmacology Humans Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Spectrometry, Mass, Fast Atom Bombardment Trees Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:	Eight minor taxanes have been identified for the first time in Taxus canadensis needles. Four of these metabolites are new taxane analogues: 7-acetyl-10-deacetyltaxol (1), 2‘-acetyl-7-epi-cephalomannine (2), 10-deacetyl-10-oxo-7-epi-cephalomannine (3), and 10-acetylglycollylbaccatin VI (4).
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0004449