The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM

Fanconi anaemia (FA) is a chromosomal instability syndrome with autosomal recessive inheritance. We have identified the gene mutated in Fanconi anaemia group F patients by complementation cloning. FANCF has no introns and encodes a polypeptide with homology to the prokaryotic RNA binding protein ROM...

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Veröffentlicht in:	Nature genetics 2000-01, Vol.24 (1), p.15-16
Hauptverfasser:	Scheper, Rik J, de Winter, Johan P, van der Weel, Laura, Alon, Noa, Waisfisz, Quinten, Pronk, Jan C, Mathew, Christopher G, Buchwald, Manuel, Rooimans, Martin A, Hoatlin, Maureen E, Arwert, Fré, Joenje, Hans, de Groot, Jan, van Berkel, Carola G.M, Bosnoyan-Collins, Lucine, Zhi, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Anemia Anemias. Hemoglobinopathies Binding proteins Biological and medical sciences Cancer Cloning Diseases of red blood cells DNA, Complementary FANCA gene FANCC gene FANCD gene FANCE gene FANCF gene FANCF protein FANCG gene Fanconi Anemia - genetics Fanconi Anemia Complementation Group F Protein Fanconi's anemia Genes Genetic aspects Genetics Hematologic and hematopoietic diseases Hospitals Humans Medical sciences Molecular Sequence Data Polypeptides Proteins Recombinant Proteins - chemistry Recombinant Proteins - genetics Ribonucleic acid RNA RNA-Binding Proteins - chemistry RNA-Binding Proteins - genetics ROM protein Sequence Homology, Amino Acid
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Zusammenfassung:	Fanconi anaemia (FA) is a chromosomal instability syndrome with autosomal recessive inheritance. We have identified the gene mutated in Fanconi anaemia group F patients by complementation cloning. FANCF has no introns and encodes a polypeptide with homology to the prokaryotic RNA binding protein ROM.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/71626