Lack of Benefit of Intravenous Immune Globulin in a Murine Model of Group A Streptococcal Necrotizing Fasciitis
Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin-S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treat...
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| Veröffentlicht in: | The Journal of infectious diseases 2000-01, Vol.181 (1), p.230-234 |
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| container_title | The Journal of infectious diseases |
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| creator | Patel, Robin Rouse, Mark S. Florez, Monica V. Piper, Kerryl E. Cockerill, Franklin R. Wilson, Walter R. Steckelberg, James M. |
| description | Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin-S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treatment regimens that contained penicillin or clindamycin were more effective (P |
| doi_str_mv | 10.1086/315198 |
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As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treatment regimens that contained penicillin or clindamycin were more effective (P <.05) than no treatment or treatment with IVIG alone. No significant differences were detected among results of treatment with penicillin, penicillin/clindamycin, penicillin/IVIG, clindamycin/IVIG, or all agents combined. Clindamycin alone was less effective than penicillin/IVIG (P =.02), penicillin/clindamycin (P =.009), clindamycin/IVIG (P =.04), or all agents combined (P =.02). No antagonism was observed with the addition of clindamycin or IVIG to penicillin.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/315198</identifier><identifier>PMID: 10608771</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Animals ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Antimicrobials ; Bacterial diseases ; Bacteriology ; Biological and medical sciences ; Clindamycin - therapeutic use ; Drug Therapy, Combination ; Experimental bacterial diseases and models ; Fasciitis, Necrotizing - drug therapy ; Fundamental and applied biological sciences. Psychology ; Immunoglobulins ; Immunoglobulins, Intravenous - therapeutic use ; Infections ; Infectious diseases ; Major Articles ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Microbial Sensitivity Tests ; Microbiology ; Mortality ; Necrotizing fasciitis ; Penicillin ; Penicillins - therapeutic use ; Septic shock ; Streptococcal infections ; Streptococcus pyogenes ; Streptococcus pyogenes - drug effects ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><ispartof>The Journal of infectious diseases, 2000-01, Vol.181 (1), p.230-234</ispartof><rights>Copyright 2000 Infectious Diseases Society of America</rights><rights>2000 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jan 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-70edf891ddc8048caf4c2e1382c0d94d8ea7da208b8c23b6a85c8d60b67dfdd23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30111294$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30111294$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,4024,27923,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1248358$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10608771$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Robin</creatorcontrib><creatorcontrib>Rouse, Mark S.</creatorcontrib><creatorcontrib>Florez, Monica V.</creatorcontrib><creatorcontrib>Piper, Kerryl E.</creatorcontrib><creatorcontrib>Cockerill, Franklin R.</creatorcontrib><creatorcontrib>Wilson, Walter R.</creatorcontrib><creatorcontrib>Steckelberg, James M.</creatorcontrib><title>Lack of Benefit of Intravenous Immune Globulin in a Murine Model of Group A Streptococcal Necrotizing Fasciitis</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><description>Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin-S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treatment regimens that contained penicillin or clindamycin were more effective (P <.05) than no treatment or treatment with IVIG alone. No significant differences were detected among results of treatment with penicillin, penicillin/clindamycin, penicillin/IVIG, clindamycin/IVIG, or all agents combined. Clindamycin alone was less effective than penicillin/IVIG (P =.02), penicillin/clindamycin (P =.009), clindamycin/IVIG (P =.04), or all agents combined (P =.02). No antagonism was observed with the addition of clindamycin or IVIG to penicillin.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Antimicrobials</subject><subject>Bacterial diseases</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Clindamycin - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Experimental bacterial diseases and models</subject><subject>Fasciitis, Necrotizing - drug therapy</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunoglobulins</subject><subject>Immunoglobulins, Intravenous - therapeutic use</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Major Articles</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Mortality</subject><subject>Necrotizing fasciitis</subject><subject>Penicillin</subject><subject>Penicillins - therapeutic use</subject><subject>Septic shock</subject><subject>Streptococcal infections</subject><subject>Streptococcus pyogenes</subject><subject>Streptococcus pyogenes - drug effects</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFDEUxQdR7Fr1GyhBxLfRm3-TzGMtdruw1QcVpC8hk2Qk25nJNsmI-unNMkstvgiBG3J-98DJqarnGN5ikM07ijlu5YNqhTkVddNg-rBaARBSY9m2J9WTlHYAwGgjHlcnGBqQQuBVFbba3KDQo_ducr3Ph-tmylH_cFOYE9qM4zw5tB5CNw9-QuVodDVHXx6vgnXDYWEdw7xHZ-hzjm6fgwnG6AF9dCaG7H_76Tu60Ml4n316Wj3q9ZDcs-M8rb5efPhyfllvP60352fb2jDOci3A2V622FojgUmje2aIw1QSA7ZlVjotrCYgO2kI7RotuZG2ga4RtreW0NPqzeK7j-F2dimr0SfjhkFPruRSAoovJ_BfEEuQjElewFf_gLswx6mEUITQFmjb3nMr0VOKrlf76EcdfykM6lCUWooq4Muj29yNzt7DlmYK8PoIlK_TQx_1ZHz6yxEmKT_4vFiwXcoh3skUMMakZUWvF92n7H7e6TreqEZQwdXlt2t1zQVhGHNF6R_3nrFa</recordid><startdate>200001</startdate><enddate>200001</enddate><creator>Patel, Robin</creator><creator>Rouse, Mark S.</creator><creator>Florez, Monica V.</creator><creator>Piper, Kerryl E.</creator><creator>Cockerill, Franklin R.</creator><creator>Wilson, Walter R.</creator><creator>Steckelberg, James M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200001</creationdate><title>Lack of Benefit of Intravenous Immune Globulin in a Murine Model of Group A Streptococcal Necrotizing Fasciitis</title><author>Patel, Robin ; Rouse, Mark S. ; Florez, Monica V. ; Piper, Kerryl E. ; Cockerill, Franklin R. ; Wilson, Walter R. ; Steckelberg, James M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-70edf891ddc8048caf4c2e1382c0d94d8ea7da208b8c23b6a85c8d60b67dfdd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Antimicrobials</topic><topic>Bacterial diseases</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Clindamycin - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Experimental bacterial diseases and models</topic><topic>Fasciitis, Necrotizing - drug therapy</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunoglobulins</topic><topic>Immunoglobulins, Intravenous - therapeutic use</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Major Articles</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Mortality</topic><topic>Necrotizing fasciitis</topic><topic>Penicillin</topic><topic>Penicillins - therapeutic use</topic><topic>Septic shock</topic><topic>Streptococcal infections</topic><topic>Streptococcus pyogenes</topic><topic>Streptococcus pyogenes - drug effects</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Robin</creatorcontrib><creatorcontrib>Rouse, Mark S.</creatorcontrib><creatorcontrib>Florez, Monica V.</creatorcontrib><creatorcontrib>Piper, Kerryl E.</creatorcontrib><creatorcontrib>Cockerill, Franklin R.</creatorcontrib><creatorcontrib>Wilson, Walter R.</creatorcontrib><creatorcontrib>Steckelberg, James M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Robin</au><au>Rouse, Mark S.</au><au>Florez, Monica V.</au><au>Piper, Kerryl E.</au><au>Cockerill, Franklin R.</au><au>Wilson, Walter R.</au><au>Steckelberg, James M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of Benefit of Intravenous Immune Globulin in a Murine Model of Group A Streptococcal Necrotizing Fasciitis</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2000-01</date><risdate>2000</risdate><volume>181</volume><issue>1</issue><spage>230</spage><epage>234</epage><pages>230-234</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin-S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treatment regimens that contained penicillin or clindamycin were more effective (P <.05) than no treatment or treatment with IVIG alone. No significant differences were detected among results of treatment with penicillin, penicillin/clindamycin, penicillin/IVIG, clindamycin/IVIG, or all agents combined. Clindamycin alone was less effective than penicillin/IVIG (P =.02), penicillin/clindamycin (P =.009), clindamycin/IVIG (P =.04), or all agents combined (P =.02). No antagonism was observed with the addition of clindamycin or IVIG to penicillin.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>10608771</pmid><doi>10.1086/315198</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2000-01, Vol.181 (1), p.230-234 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animals Anti-Bacterial Agents - therapeutic use Antibiotics Antimicrobials Bacterial diseases Bacteriology Biological and medical sciences Clindamycin - therapeutic use Drug Therapy, Combination Experimental bacterial diseases and models Fasciitis, Necrotizing - drug therapy Fundamental and applied biological sciences. Psychology Immunoglobulins Immunoglobulins, Intravenous - therapeutic use Infections Infectious diseases Major Articles Medical sciences Mice Mice, Inbred C57BL Microbial Sensitivity Tests Microbiology Mortality Necrotizing fasciitis Penicillin Penicillins - therapeutic use Septic shock Streptococcal infections Streptococcus pyogenes Streptococcus pyogenes - drug effects Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies |
| title | Lack of Benefit of Intravenous Immune Globulin in a Murine Model of Group A Streptococcal Necrotizing Fasciitis |
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