Lack of Benefit of Intravenous Immune Globulin in a Murine Model of Group A Streptococcal Necrotizing Fasciitis

Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin-S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treat...

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Veröffentlicht in:	The Journal of infectious diseases 2000-01, Vol.181 (1), p.230-234
Hauptverfasser:	Patel, Robin, Rouse, Mark S., Florez, Monica V., Piper, Kerryl E., Cockerill, Franklin R., Wilson, Walter R., Steckelberg, James M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - therapeutic use Antibiotics Antimicrobials Bacterial diseases Bacteriology Biological and medical sciences Clindamycin - therapeutic use Drug Therapy, Combination Experimental bacterial diseases and models Fasciitis, Necrotizing - drug therapy Fundamental and applied biological sciences. Psychology Immunoglobulins Immunoglobulins, Intravenous - therapeutic use Infections Infectious diseases Major Articles Medical sciences Mice Mice, Inbred C57BL Microbial Sensitivity Tests Microbiology Mortality Necrotizing fasciitis Penicillin Penicillins - therapeutic use Septic shock Streptococcal infections Streptococcus pyogenes Streptococcus pyogenes - drug effects Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
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Zusammenfassung:	Penicillin, clindamycin, and intravenous immune globulin (Venoglobulin-S; IVIG) alone and in combination were studied in a murine model of group A streptococcal necrotizing fasciitis. As assessed by bacterial clearance, treatment with IVIG was not significantly different from no treatment. All treatment regimens that contained penicillin or clindamycin were more effective (P
ISSN:	0022-1899 1537-6613
DOI:	10.1086/315198