Effect of exercise training on metallothionein levels of hypertensive rats
Because oxidative stress may be involved in arterial hypertension by affecting the balance between relaxing and contracting factors of vascular smooth muscle, the training-induced adaptation of antioxidant defenses could be implicated in the antihypertensive effect of chronic exercise. It has been s...
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Veröffentlicht in: | Medicine and science in sports and exercise 2001-05, Vol.33 (5), p.724-728 |
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description | Because oxidative stress may be involved in arterial hypertension by affecting the balance between relaxing and contracting factors of vascular smooth muscle, the training-induced adaptation of antioxidant defenses could be implicated in the antihypertensive effect of chronic exercise. It has been suggested that metallothionein (MT), a metal-binding protein, plays an antioxidant role in mammals. The aim of this experiment was to study whether chronic exercise (swimming) influences both the development of arterial hypertension in spontaneously hypertensive rats (SHR) and the modification of MT levels.
Male SHR and Wistar Kyoto (WKY) rats as control were trained to swim 1 h.d-1 5 d.wk-1 for 8 wk and sacrificed 72 h after the last exercise period. MT and total thiol levels were then measured.
Exercise training 1) reduced systolic blood pressure and heart rate in both SHR WKY rats, and 2) was associated with a decrease in hepatic and cardiac MT levels; there was an increase in the aortic MT amounts in exercised SHR only. No modifications were noted in the gastrocnemius muscle or kidneys. In exercised animals, total thiols were lower in the liver but not in kidneys.
Chronic exercise induced a reduction in arterial hypertension development in SHR rats and an adaptation of the MT levels in cardiac, hepatic, and aortic tissues. Further experiments are needed to pinpoint the role of the MT in these two cases in which oxidative stress occurs. |
doi_str_mv | 10.1097/00005768-200105000-00007 |
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Male SHR and Wistar Kyoto (WKY) rats as control were trained to swim 1 h.d-1 5 d.wk-1 for 8 wk and sacrificed 72 h after the last exercise period. MT and total thiol levels were then measured.
Exercise training 1) reduced systolic blood pressure and heart rate in both SHR WKY rats, and 2) was associated with a decrease in hepatic and cardiac MT levels; there was an increase in the aortic MT amounts in exercised SHR only. No modifications were noted in the gastrocnemius muscle or kidneys. In exercised animals, total thiols were lower in the liver but not in kidneys.
Chronic exercise induced a reduction in arterial hypertension development in SHR rats and an adaptation of the MT levels in cardiac, hepatic, and aortic tissues. Further experiments are needed to pinpoint the role of the MT in these two cases in which oxidative stress occurs.</description><identifier>ISSN: 0195-9131</identifier><identifier>EISSN: 1530-0315</identifier><identifier>DOI: 10.1097/00005768-200105000-00007</identifier><identifier>PMID: 11323539</identifier><identifier>CODEN: MSPEDA</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Aorta - chemistry ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Disease Models, Animal ; Experimental diseases ; Heart Rate ; Hypertension - physiopathology ; Hypertension - veterinary ; Liver - chemistry ; Male ; Medical sciences ; Metallothionein - analysis ; Myocardium - chemistry ; Physical Conditioning, Animal ; Rats ; Rats, Inbred SHR ; Rats, Wistar ; Space life sciences</subject><ispartof>Medicine and science in sports and exercise, 2001-05, Vol.33 (5), p.724-728</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-10716b3cd35ab9efd5cd132bb43ccdf2f6077ea6e7b1ebf496d2e438009a13de3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1063767$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11323539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHAUMONT, Sylvie Bobillier</creatorcontrib><creatorcontrib>MAUPOIL, Veronique</creatorcontrib><creatorcontrib>LAHET, Jean Jacques</creatorcontrib><creatorcontrib>BERTHELOT, Alain</creatorcontrib><title>Effect of exercise training on metallothionein levels of hypertensive rats</title><title>Medicine and science in sports and exercise</title><addtitle>Med Sci Sports Exerc</addtitle><description>Because oxidative stress may be involved in arterial hypertension by affecting the balance between relaxing and contracting factors of vascular smooth muscle, the training-induced adaptation of antioxidant defenses could be implicated in the antihypertensive effect of chronic exercise. It has been suggested that metallothionein (MT), a metal-binding protein, plays an antioxidant role in mammals. The aim of this experiment was to study whether chronic exercise (swimming) influences both the development of arterial hypertension in spontaneously hypertensive rats (SHR) and the modification of MT levels.
Male SHR and Wistar Kyoto (WKY) rats as control were trained to swim 1 h.d-1 5 d.wk-1 for 8 wk and sacrificed 72 h after the last exercise period. MT and total thiol levels were then measured.
Exercise training 1) reduced systolic blood pressure and heart rate in both SHR WKY rats, and 2) was associated with a decrease in hepatic and cardiac MT levels; there was an increase in the aortic MT amounts in exercised SHR only. No modifications were noted in the gastrocnemius muscle or kidneys. In exercised animals, total thiols were lower in the liver but not in kidneys.
Chronic exercise induced a reduction in arterial hypertension development in SHR rats and an adaptation of the MT levels in cardiac, hepatic, and aortic tissues. Further experiments are needed to pinpoint the role of the MT in these two cases in which oxidative stress occurs.</description><subject>Animals</subject><subject>Aorta - chemistry</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Disease Models, Animal</subject><subject>Experimental diseases</subject><subject>Heart Rate</subject><subject>Hypertension - physiopathology</subject><subject>Hypertension - veterinary</subject><subject>Liver - chemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metallothionein - analysis</subject><subject>Myocardium - chemistry</subject><subject>Physical Conditioning, Animal</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Wistar</subject><subject>Space life sciences</subject><issn>0195-9131</issn><issn>1530-0315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlOwzAQQC0EoqXwCygHxC3gycRxckRV2VSJC5wjxxnToCzFTiv69zg0LDfmMprRm0WPsQD4FfBMXnMfQiZpGHEOXPgqHFrygE1BoC8QxCGbcshEmAHChJ049zYQiHDMJgAYocBsyh4XxpDug84E9EFWV46C3qqqrdrXoGuDhnpV112_qrqWqjaoaUu1G_DVbk22p9ZVWwqs6t0pOzKqdnQ25hl7uV08z-_D5dPdw_xmGWqU0IfAJSQF6hKFKjIypdClf6coYtS6NJFJuJSkEpIFUGHiLCkjijHlPFOAJeGMXe73rm33viHX503lNNW1aqnbuFzylMdxhP-CkEYgRZp4MN2D2nbOWTL52laNsrsceD4Iz7-F5z_Cv1rSj56PNzZFQ-Xv4GjYAxcjoJxWtbGq9ZL_HEhQJhI_AUEWiLw</recordid><startdate>20010501</startdate><enddate>20010501</enddate><creator>CHAUMONT, Sylvie Bobillier</creator><creator>MAUPOIL, Veronique</creator><creator>LAHET, Jean Jacques</creator><creator>BERTHELOT, Alain</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20010501</creationdate><title>Effect of exercise training on metallothionein levels of hypertensive rats</title><author>CHAUMONT, Sylvie Bobillier ; MAUPOIL, Veronique ; LAHET, Jean Jacques ; BERTHELOT, Alain</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-10716b3cd35ab9efd5cd132bb43ccdf2f6077ea6e7b1ebf496d2e438009a13de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Aorta - chemistry</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Disease Models, Animal</topic><topic>Experimental diseases</topic><topic>Heart Rate</topic><topic>Hypertension - physiopathology</topic><topic>Hypertension - veterinary</topic><topic>Liver - chemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metallothionein - analysis</topic><topic>Myocardium - chemistry</topic><topic>Physical Conditioning, Animal</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Wistar</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CHAUMONT, Sylvie Bobillier</creatorcontrib><creatorcontrib>MAUPOIL, Veronique</creatorcontrib><creatorcontrib>LAHET, Jean Jacques</creatorcontrib><creatorcontrib>BERTHELOT, Alain</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Medicine and science in sports and exercise</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CHAUMONT, Sylvie Bobillier</au><au>MAUPOIL, Veronique</au><au>LAHET, Jean Jacques</au><au>BERTHELOT, Alain</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of exercise training on metallothionein levels of hypertensive rats</atitle><jtitle>Medicine and science in sports and exercise</jtitle><addtitle>Med Sci Sports Exerc</addtitle><date>2001-05-01</date><risdate>2001</risdate><volume>33</volume><issue>5</issue><spage>724</spage><epage>728</epage><pages>724-728</pages><issn>0195-9131</issn><eissn>1530-0315</eissn><coden>MSPEDA</coden><abstract>Because oxidative stress may be involved in arterial hypertension by affecting the balance between relaxing and contracting factors of vascular smooth muscle, the training-induced adaptation of antioxidant defenses could be implicated in the antihypertensive effect of chronic exercise. It has been suggested that metallothionein (MT), a metal-binding protein, plays an antioxidant role in mammals. The aim of this experiment was to study whether chronic exercise (swimming) influences both the development of arterial hypertension in spontaneously hypertensive rats (SHR) and the modification of MT levels.
Male SHR and Wistar Kyoto (WKY) rats as control were trained to swim 1 h.d-1 5 d.wk-1 for 8 wk and sacrificed 72 h after the last exercise period. MT and total thiol levels were then measured.
Exercise training 1) reduced systolic blood pressure and heart rate in both SHR WKY rats, and 2) was associated with a decrease in hepatic and cardiac MT levels; there was an increase in the aortic MT amounts in exercised SHR only. No modifications were noted in the gastrocnemius muscle or kidneys. In exercised animals, total thiols were lower in the liver but not in kidneys.
Chronic exercise induced a reduction in arterial hypertension development in SHR rats and an adaptation of the MT levels in cardiac, hepatic, and aortic tissues. Further experiments are needed to pinpoint the role of the MT in these two cases in which oxidative stress occurs.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11323539</pmid><doi>10.1097/00005768-200105000-00007</doi><tpages>5</tpages></addata></record> |
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subjects | Animals Aorta - chemistry Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Disease Models, Animal Experimental diseases Heart Rate Hypertension - physiopathology Hypertension - veterinary Liver - chemistry Male Medical sciences Metallothionein - analysis Myocardium - chemistry Physical Conditioning, Animal Rats Rats, Inbred SHR Rats, Wistar Space life sciences |
title | Effect of exercise training on metallothionein levels of hypertensive rats |
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