Ongoing HIV dissemination during HAART

Highly active anti-retroviral therapy significantly suppresses viral replication, but does not lead to complete eradication of HIV. Here the authors discuss a new model of viral decay, which in addition to the half-life of the viral resevoirs, takes into account infection bursts and immune activatio...

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Veröffentlicht in:	Nature medicine 1999-10, Vol.5 (10), p.1099-1104
Hauptverfasser:	Grossman, Zvi, Polis, Michael, Feinberg, Mark B, Grossman, Zehava, Levi, Itschak, Jankelevich, Shirley, Yarchoan, Robert, Boon, Jacob, de Wolf, Frank, Lange, Joep M.A, Goudsmit, Jaap, Dimitrov, Dimiter S, Paul, William E
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Anti-HIV Agents - therapeutic use Biomedical and Life Sciences Biomedicine Cancer Research CD4-Positive T-Lymphocytes - virology commentary Drug Therapy, Combination highly active antiretroviral therapy HIV - drug effects HIV - growth & development HIV - immunology HIV Infections - blood HIV Infections - drug therapy HIV Infections - immunology Human immunodeficiency virus Humans Immunologic Memory Infectious Diseases Metabolic Diseases Models, Immunological Molecular Medicine Neurosciences RNA, Viral - blood Virus Latency Virus Replication - drug effects
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Beschreibung
Zusammenfassung:	Highly active anti-retroviral therapy significantly suppresses viral replication, but does not lead to complete eradication of HIV. Here the authors discuss a new model of viral decay, which in addition to the half-life of the viral resevoirs, takes into account infection bursts and immune activation events.
ISSN:	1078-8956 1546-170X
DOI:	10.1038/13410