Selenium Deficiency Is Associated With Shedding of HIV-1-Infected Cells in the Female Genital Tract

OBJECTIVE:To assess the relation between selenium deficiency and vaginal or cervical shedding of HIV-1-infected cells. DESIGN:Cross-sectional study of 318 HIV-1 seropositive women in Mombasa, Kenya. METHODS:Vaginal and cervical swab specimens were tested for the presence of HIV-1 DNA by polymerase c...

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Veröffentlicht in:	Journal of acquired immune deficiency syndromes (1999) 2001-04, Vol.26 (4), p.360-364
Hauptverfasser:	Baeten, Jared M, Mostad, Sara B, Hughes, Martin P, Overbaugh, Julie, Bankson, Daniel D, Mandaliya, Kishorchandra, Ndinya-Achola, Jeckoniah O, Bwayo, Job J, Kreiss, Joan K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult AIDS/HIV Biological and medical sciences CD4 Lymphocyte Count Cells Cervix Uteri - pathology Cervix Uteri - virology Cross-Sectional Studies DNA, Viral - analysis Experimental viral diseases and models Female Fundamental and applied biological sciences. Psychology HIV HIV Infections - blood HIV Infections - pathology HIV Infections - transmission HIV Infections - virology HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Infectious diseases Kenya Logistic Models Medical sciences Microbiology Middle Aged Multivariate Analysis Nutrition Odds Ratio Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Reproductive system Selenium - blood Selenium - deficiency shedding Vagina - pathology Vagina - virology Viral diseases Virology Virus Shedding Vitamin A Deficiency - blood Vitamin A Deficiency - virology Vitamin E - blood
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Zusammenfassung:	OBJECTIVE:To assess the relation between selenium deficiency and vaginal or cervical shedding of HIV-1-infected cells. DESIGN:Cross-sectional study of 318 HIV-1 seropositive women in Mombasa, Kenya. METHODS:Vaginal and cervical swab specimens were tested for the presence of HIV-1 DNA by polymerase chain reaction. Multivariate logistic regression models, adjusting for CD4 count and vitamin A deficiency, were used. RESULTS:Selenium deficiency (defined as levels
ISSN:	1525-4135 1944-7884
DOI:	10.1097/00042560-200104010-00013