Antidiabetic properties of aqueous barks extract of Parinari excelsa in alloxan-induced diabetic rats

The aqueous extract of the Parinari excelsa barks at doses of 100 and 300 mg/kg/day for 7 days has a significant antihyperglycemic effect on alloxan-induced diabetic rats. At the same dose the acute oral administration of aqueous extract of the P. excelsa barks (100 and 300 mg/kg) induced a signific...

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Veröffentlicht in:	Fitoterapia 2008-06, Vol.79 (4), p.267-270
Hauptverfasser:	Ndiaye, M., Diatta, W., Sy, A.N., Dièye, A.M., Faye, B., Bassène, E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloxan Alloxanic rats Animals Antidiabetic Biological and medical sciences Chrysobalanaceae - chemistry Diabetes Mellitus, Experimental - drug therapy Dose-Response Relationship, Drug General pharmacology Glucose Tolerance Test Glyburide - pharmacology Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology Male Medical sciences Parinari excelsa Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Rats
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Zusammenfassung:	The aqueous extract of the Parinari excelsa barks at doses of 100 and 300 mg/kg/day for 7 days has a significant antihyperglycemic effect on alloxan-induced diabetic rats. At the same dose the acute oral administration of aqueous extract of the P. excelsa barks (100 and 300 mg/kg) induced a significant decrease of blood glucose on glucose-loaded normoglycaemic rats. Our results seem to confirm the rational bases for its use in traditional medicine.
ISSN:	0367-326X
DOI:	10.1016/j.fitote.2008.01.004