Differential Effects of Drug-Eluting Stents on Local Endothelium-Dependent Coronary Vasomotion

Differential Effects of Drug-Eluting Stents on Local Endothelium-Dependent Coronary Vasomotion Michalis I. Hamilos, Miodrag Ostojic, Branko Beleslin, Dragan Sagic, Ljubco Mangovski, Sinisa Stojkovic, Milan Nedeljkovic, Dejan Orlic, Bratislav Milosavljevic, Dragan Topic, Nevena Karanovic, William Wij...

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Veröffentlicht in:	Journal of the American College of Cardiology 2008-06, Vol.51 (22), p.2123-2129
Hauptverfasser:	Hamilos, Michalis I., MD, Ostojic, Miodrag, MD, PhD, Beleslin, Branko, MD, PhD, Sagic, Dragan, MD, PhD, Mangovski, Ljubco, MD, Stojkovic, Sinisa, MD, PhD, Nedeljkovic, Milan, MD, PhD, Orlic, Dejan, MD, Milosavljevic, Bratislav, MD, Topic, Dragan, MD, Karanovic, Nevena, MD, PhD, Wijns, William, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiology Cardiovascular Cardiovascular disease Coronary Angiography Coronary vessels Coronary Vessels - drug effects Coronary Vessels - physiopathology Drug-Eluting Stents Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Female Heart Heart rate Hemodynamics Humans Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Internal Medicine Intubation Male Medical imaging Middle Aged Paclitaxel - pharmacology Paclitaxel - therapeutic use Prospective Studies Sirolimus - analogs & derivatives Sirolimus - pharmacology Sirolimus - therapeutic use Stents Vasoconstriction - drug effects Vasodilation - drug effects
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Zusammenfassung:	Differential Effects of Drug-Eluting Stents on Local Endothelium-Dependent Coronary Vasomotion Michalis I. Hamilos, Miodrag Ostojic, Branko Beleslin, Dragan Sagic, Ljubco Mangovski, Sinisa Stojkovic, Milan Nedeljkovic, Dejan Orlic, Bratislav Milosavljevic, Dragan Topic, Nevena Karanovic, William Wijns, on behalf of the NOBORI CORE Investigators In the present study we compared coronary vasomotion after implantation of biolimus A9-eluting stents (BES) (n = 19) and sirolimus-eluting stents (SES) (n = 15) 9 months after stent implantation. Endothelium-dependent and -independent coronary vasomotion were tested proximally and distally to the stent as well as at a reference segment. Patients with SES showed vasoconstriction in segments proximal and distal to the stent, whereas patients with BES showed vasodilatation. These results are indicative of preserved endothelial function after BES implantation.
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2007.12.059