The Berkeleyamides, Amides from the Acid Lake Fungus Penicillum rubrum

We previously reported several novel bioactive hybrid polyketide-terpenoid metabolites from a deep water Penicillium rubrum isolated from Berkeley Pit Lake, Butte, Montana. In this paper we report the structures of four new amides, berkeleyamides A−D (1, 4, 5, 7), isolated from extracts of this fung...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2008-05, Vol.71 (5), p.856-860
Hauptverfasser:	Stierle, Andrea A., Stierle, Donald B., Patacini, Brianna
Format:	Artikel
Sprache:	eng
Schlagworte:	amides Amides - chemistry Amides - isolation & purification Amides - pharmacology Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology berkeleyamide Biological and medical sciences Caspase Inhibitors chemical structure Fundamental and applied biological sciences. Psychology General aspects Hydrogen-Ion Concentration Matrix Metalloproteinase Inhibitors Microbiology Molecular Structure Montana Penicillium Penicillium - chemistry Penicillum rubrum Protease Inhibitors - chemistry Protease Inhibitors - isolation & purification Protease Inhibitors - pharmacology Signal Transduction spectral analysis stereochemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	We previously reported several novel bioactive hybrid polyketide-terpenoid metabolites from a deep water Penicillium rubrum isolated from Berkeley Pit Lake, Butte, Montana. In this paper we report the structures of four new amides, berkeleyamides A−D (1, 4, 5, 7), isolated from extracts of this fungus. The structures of these compounds were deduced by analysis of NMR data, chemical derivatization, and comparison of their spectroscopic data to those of known compounds.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0705054