Hypertension Impairs Postnatal Vasculogenesis: Role of Antihypertensive Agents

We analyzed the effect of hypertension on postischemic vasculogenesis. Ischemia was induced by right femoral artery ligature in Wistar Kyoto rats (WKY) or spontaneously hypertensive rats (SHR) treated with or without angiotensin-converting enzyme inhibitor (Perindopril, 0.76 mg/kg/d) and angiotensin...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2008-06, Vol.51 (6), p.1537-1544
Hauptverfasser:	You, Dong, Cochain, Clément, Loinard, Céline, Vilar, José, Mees, Barend, Duriez, Micheline, Lévy, Bernard I, Silvestre, Jean-Sébastien
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - pharmacology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Pressure - physiology Bone Marrow Cells - cytology Bone Marrow Cells - physiology Cardiology. Vascular system Cell Differentiation - physiology Clinical manifestations. Epidemiology. Investigative techniques. Etiology Disease Models, Animal Endothelium, Vascular - cytology Endothelium, Vascular - physiology Hindlimb - blood supply Hydralazine - pharmacology Hypertension - drug therapy Hypertension - pathology Hypertension - physiopathology Ischemia - pathology Ischemia - physiopathology Ligation Losartan - pharmacology Male Medical sciences Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - physiology Oxidative Stress - drug effects Oxidative Stress - physiology Perindopril - pharmacology Rats Rats, Inbred SHR Rats, Inbred WKY Stem Cells - cytology Stem Cells - physiology
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Zusammenfassung:	We analyzed the effect of hypertension on postischemic vasculogenesis. Ischemia was induced by right femoral artery ligature in Wistar Kyoto rats (WKY) or spontaneously hypertensive rats (SHR) treated with or without angiotensin-converting enzyme inhibitor (Perindopril, 0.76 mg/kg/d) and angiotensin type 1 receptor blocker (losartan, 30 mg/kg/d). Basal postischemic neovascularization was reduced in SHR compared to WKY (P
ISSN:	0194-911X 1524-4563
DOI:	10.1161/HYPERTENSIONAHA.107.109066