Mouse chromosome 4

This year's report incorporates 78 new genetic markers into the consensus linkage map. Of these markers, ten have a known, mapped human homolog. The murine gene, followed by the human homolog and the human chromosomal location in parenthesis are as follows: Cpt2 = CPT2 (1p32); Cyp2j5 and Cyp2j6 = CYP2J2 (1p31.3-p31.2); Guca1b = GUCA2B (1p34-p33); Htr6 = HTR6 (1p36-1p35); Hub = ELAVL2 (9p21); Hud = ELAVL4 (1p34); Matn1 = MATN1 (1p35); Mmp16 = MMP16 (8q21.3-q22.1); Tgfbr1 = TGFBR1 (9q33-q34). In the case of the Cyp genes, two genes have been identified in mouse while only a single gene has been identified in humans. Mouse Chromosome (Chr) 4 shares significant stretches of linkage homology with human Chr 1, 6, 8, 9 and 21 (34245; 23572). The entire distal half of mouse Chr 4 is homologous with human Chr 1p. There have been four changes in nomenclature of genetic loci on Chr 4. Gene names and/or symbols that have been changed by the Nomenclature Committee include: Cerr1 changed to Cer1; Dana changed to D4H1s1733E; Zie changed to Gk1f; and Etl2 changed to I11 1ra2.