Cytotoxic Diterpenoids from Euphorbia helioscopia

Four new jatrophane-type diterpenoids (1−4), together with 16 known related compounds, were isolated from the Chinese medicinal plant Euphorbia helioscopia. The structures of 1−4 were determined on the basis of spectroscopic and chemical methods. Cytotoxicity of the isolated compounds against HeLa a...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2008-05, Vol.71 (5), p.873-876
Hauptverfasser:	Lu, Zhi-Qiang, Guan, Shu-Hong, Li, Xing-Nuo, Chen, Guang-Tong, Zhang, Jin-Qiang, Huang, Hui-Lian, Liu, Xuan, Guo, De-An
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Diterpenes, Abietane - pharmacology Drug Screening Assays, Antitumor Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology Euphorbia - chemistry General pharmacology HeLa Cells Humans Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments
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Zusammenfassung:	Four new jatrophane-type diterpenoids (1−4), together with 16 known related compounds, were isolated from the Chinese medicinal plant Euphorbia helioscopia. The structures of 1−4 were determined on the basis of spectroscopic and chemical methods. Cytotoxicity of the isolated compounds against HeLa and MDA-MB-231 cells was evaluated, with only helioscopinolide A (5) and euphornin (3a) being active.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0706163