Ancistroealaines A and B, Two New Bioactive Naphthylisoquinolines, and Related Naphthoic Acids from Ancistrocladus ealaensis

Two new 5,8‘-coupled naphthylisoquinoline alkaloids, ancistroealaines A (1) and B (2), eleutherolic acid (3), and two naphthoic acids, ancistronaphthoic acid A (4) and B (5), have been isolated from Ancistrocladus ealaensis. Their structures were determined by spectroscopic, chemical, and chiroptica...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-11, Vol.63 (11), p.1465-1470
Hauptverfasser:	Bringmann, Gerhard, Hamm, Andreas, Günther, Christian, Michel, Manuela, Brun, Reto, Mudogo, Virima
Format:	Artikel
Sprache:	eng
Schlagworte:	Ancistrocladus ealaensis ancistroealaine A ancistroealaine B ancistronaphthoic acid A ancistronaphthoic acid B Animals Antimalarials - isolation & purification Antimalarials - pharmacology Antiprotozoal Agents - isolation & purification Antiprotozoal Agents - pharmacology Biological and medical sciences Cell Line Chromatography, High Pressure Liquid Congo eleutherolic acid General pharmacology Humans Isoquinolines - isolation & purification Isoquinolines - pharmacology Leishmania donovani Magnetic Resonance Spectroscopy Medical sciences Mice Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Rats Trypanocidal Agents - isolation & purification Trypanocidal Agents - pharmacology Trypanosoma - drug effects
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Zusammenfassung:	Two new 5,8‘-coupled naphthylisoquinoline alkaloids, ancistroealaines A (1) and B (2), eleutherolic acid (3), and two naphthoic acids, ancistronaphthoic acid A (4) and B (5), have been isolated from Ancistrocladus ealaensis. Their structures were determined by spectroscopic, chemical, and chiroptical methods. Ancistroealaine A (1) exhibited activity against Leishmania donovani and Trypanosoma cruzi in vitro.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np000247+