Chronic potassium depletion induces renal injury, salt sensitivity, and hypertension in young rats

Chronic potassium depletion induces renal injury, salt sensitivity, and hypertension in young rats. Chronic hypokalemia has been associated with renal hypertrophy, interstitial disease, and hypertension in both adult animals and humans. However, the effects of potassium (K+) depletion on the rapidly...

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Veröffentlicht in:	Kidney international 2001-05, Vol.59 (5), p.1850-1858
Hauptverfasser:	Ray, Patricio E., Suga, Shin-Ichi, Liu, Xue-Hui, Huang, Xiuling, Johnson, Richard J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Pressure Chronic Disease chronic hypokalemia Drug Resistance Growth Disorders - etiology Hypertension - etiology Hypertension - physiopathology Hypokalemia - complications Hypokalemia - pathology Hypokalemia - physiopathology interstitial disease Kidney - injuries Kidney - pathology Kidney - physiopathology kidney development Male Potassium, Dietary - administration & dosage Rats Rats, Sprague-Dawley renal hypertrophy renin-angiotensin system Renin-Angiotensin System - physiology Sodium Chloride - pharmacology
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Zusammenfassung:	Chronic potassium depletion induces renal injury, salt sensitivity, and hypertension in young rats. Chronic hypokalemia has been associated with renal hypertrophy, interstitial disease, and hypertension in both adult animals and humans. However, the effects of potassium (K+) depletion on the rapidly growing infant have not been well studied. The purpose of this study was to determine the effects of severe chronic dietary K+ depletion on blood pressure (BP) and renal structural changes in young rats. Sprague-Dawley rats (50 ± 5g) were fed either a control or a potassium-deficient diet (
ISSN:	0085-2538 1523-1755
DOI:	10.1046/j.1523-1755.2001.0590051850.x