A New Entry to Cascade Organocatalysis: Reactions of Stable Sulfur Ylides and Nitroolefins Sequentially Catalyzed by Thiourea and DMAP

A New Entry to Cascade Organocatalysis: Reactions of Stable Sulfur Ylides and Nitroolefins Sequentially Catalyzed by Thiourea and DMAP

A novel cascade organocatalysis that allows efficient and rapid access to diverse and structurally complex oxazolidin-2-ones from simple starting materials and catalysts has been developed. A possible mechanism of this reaction has been proposed based on D- and 13C-labeling experiments.

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Veröffentlicht in:Journal of the American Chemical Society 2008-06, Vol.130 (22), p.6946-6948
Hauptverfasser: Lu, Liang-Qiu, Cao, Yi-Ju, Liu, Xiao-Peng, An, Jing, Yao, Chang-Jiang, Ming, Zhi-Hui, Xiao, Wen-Jing
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes - chemistry
Catalysis
Nitro Compounds - chemistry
Oxazolidinones - chemical synthesis
Pyridines - chemistry
Sulfur Compounds - chemistry
Thiourea - chemistry
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Beschreibung
Zusammenfassung:A novel cascade organocatalysis that allows efficient and rapid access to diverse and structurally complex oxazolidin-2-ones from simple starting materials and catalysts has been developed. A possible mechanism of this reaction has been proposed based on D- and 13C-labeling experiments.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja800746q