New Butenolides from Two Marine Streptomycetes

Chemical examination of two marine Streptomycetes has resulted in the isolation of four new butenolides, namely 4,10-dihydroxy-10-methyl-dodec-2-en-1,4-olide (1), two diastereomeric 4,11-dihydroxy-10-methyl-dodec-2-en-1,4-olides (2/3), and 4-hydroxy-10-methyl-11-oxo-dodec-2-en-1,4-olide (4). The str...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2000-11, Vol.63 (11), p.1570-1572
Hauptverfasser:	Mukku, Venugopal J. R. V, Speitling, Michael, Laatsch, Hartmut, Helmke, Elisabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	4,10-dihydroxy-10-methyl-dodec-2-en-1,4-olide 4,11-Dihydroxy-10-methyl-dodec-2-en-1,4-olide 4-Butyrolactone - analogs & derivatives 4-Hydroxy-10-methyl-11-oxo-dodec-2-en-1,4-olide Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Bacteria - drug effects Bacteriology Biological and medical sciences butenolides Circular Dichroism Fermentation Fundamental and applied biological sciences. Psychology Furans - isolation & purification Furans - pharmacology Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Microbiology Morphology, structure, chemical composition Spores, Fungal - drug effects Streptomyces Streptomycetaceae - chemistry Streptomycetes
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Beschreibung
Zusammenfassung:	Chemical examination of two marine Streptomycetes has resulted in the isolation of four new butenolides, namely 4,10-dihydroxy-10-methyl-dodec-2-en-1,4-olide (1), two diastereomeric 4,11-dihydroxy-10-methyl-dodec-2-en-1,4-olides (2/3), and 4-hydroxy-10-methyl-11-oxo-dodec-2-en-1,4-olide (4). The structures were identified by interpretation of the 2D NMR and mass spectral data.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0001676