New Sulfoalkylresorcinol from Marine-derived Fungus, Zygosporium sp. KNC52
A new sulfoalkylresorcinol ( 1 ) was isolated from the marine-derived fungus, Zygosporium sp. KNC52. The structure of 1 was elucidated by spectroscopic methods including MS and NMR, and the absolute stereochemistry was determined by the modified Mosher's method. Compound 1 inhibited FtsZ polyme...
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| Veröffentlicht in: | Journal of antibiotics 2008-03, Vol.61 (3), p.192-194 |
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| container_issue | 3 |
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| container_title | Journal of antibiotics |
| container_volume | 61 |
| creator | Kanoh, Kaneo Adachi, Kyoko Matsuda, Satoru Shizuri, Yoshikazu Yasumoto, Ko Kusumi, Takenori Okumura, Kayo Kirikae, Teruo |
| description | A new sulfoalkylresorcinol (
1
) was isolated from the marine-derived fungus,
Zygosporium
sp. KNC52. The structure of
1
was elucidated by spectroscopic methods including MS and NMR, and the absolute stereochemistry was determined by the modified Mosher's method. Compound
1
inhibited FtsZ polymerization
in vitro
and exhibited weak antimicrobial activity against multi-drugresistant bacteria. |
| doi_str_mv | 10.1038/ja.2008.29 |
| format | Article |
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1
) was isolated from the marine-derived fungus,
Zygosporium
sp. KNC52. The structure of
1
was elucidated by spectroscopic methods including MS and NMR, and the absolute stereochemistry was determined by the modified Mosher's method. Compound
1
inhibited FtsZ polymerization
in vitro
and exhibited weak antimicrobial activity against multi-drugresistant bacteria.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/ja.2008.29</identifier><identifier>PMID: 18503198</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Bacteria - drug effects ; Bacterial Proteins - chemistry ; Bacteriology ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Cytoskeletal Proteins - chemistry ; Fungi - chemistry ; Fungi - metabolism ; Indicators and Reagents ; Life Sciences ; Magnetic Resonance Spectroscopy ; Medicinal Chemistry ; Microbial Sensitivity Tests ; Microbiology ; Molecular Conformation ; Organic Chemistry ; Resorcinols - chemistry ; Spectrometry, Mass, Fast Atom Bombardment</subject><ispartof>Journal of antibiotics, 2008-03, Vol.61 (3), p.192-194</ispartof><rights>Japan Antibiotics Research Association 2008</rights><rights>Copyright Nature Publishing Group Mar 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-da9dbebd5f55924d09b87e28825760b4c1249b7febdc8883fe486df30c3ffb63</citedby><cites>FETCH-LOGICAL-c445t-da9dbebd5f55924d09b87e28825760b4c1249b7febdc8883fe486df30c3ffb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18503198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kanoh, Kaneo</creatorcontrib><creatorcontrib>Adachi, Kyoko</creatorcontrib><creatorcontrib>Matsuda, Satoru</creatorcontrib><creatorcontrib>Shizuri, Yoshikazu</creatorcontrib><creatorcontrib>Yasumoto, Ko</creatorcontrib><creatorcontrib>Kusumi, Takenori</creatorcontrib><creatorcontrib>Okumura, Kayo</creatorcontrib><creatorcontrib>Kirikae, Teruo</creatorcontrib><title>New Sulfoalkylresorcinol from Marine-derived Fungus, Zygosporium sp. KNC52</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>A new sulfoalkylresorcinol (
1
) was isolated from the marine-derived fungus,
Zygosporium
sp. KNC52. The structure of
1
was elucidated by spectroscopic methods including MS and NMR, and the absolute stereochemistry was determined by the modified Mosher's method. Compound
1
inhibited FtsZ polymerization
in vitro
and exhibited weak antimicrobial activity against multi-drugresistant bacteria.</description><subject>Bacteria - drug effects</subject><subject>Bacterial Proteins - chemistry</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Cytoskeletal Proteins - chemistry</subject><subject>Fungi - chemistry</subject><subject>Fungi - metabolism</subject><subject>Indicators and Reagents</subject><subject>Life Sciences</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medicinal Chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology</subject><subject>Molecular Conformation</subject><subject>Organic Chemistry</subject><subject>Resorcinols - chemistry</subject><subject>Spectrometry, Mass, Fast Atom Bombardment</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0U1LwzAYwPEgipvTix9ACoIHtTVvTdKjDOfbnAd38lLaJhmdbVOTVdm3N2UDRQ-ecsiPf5InABwjGCFIxNUyizCEIsLJDhgiIVCIKEt2wRBCjEIhMByAA-eWEBJOuNgHAyRiSFAihuBhpj6Dl67SJqve1pVVztiibEwVaGvq4CmzZaNCqWz5oWQw6ZpF5y6D1_XCuNbYsqsD10bB42wc40Owp7PKqaPtOgLzyc18fBdOn2_vx9fTsKA0XoUyS2SuchnrOE4wlTDJBVfYXzPmDOa0QJgmOdeeFEIIohUVTGoCC6J1zsgInG2yrTXvnXKrtC5doaoqa5TpXMohZxTR5F_oZ-bLjHp4-gsuTWcb_4YUccE5Y5z3ufONKqxxziqdtrasM7tOEUz7f0iXWd8UKe7xyTbZ5bWS33Q7eA8uNsD5rWah7I8z_-a-ANbjkDY</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Kanoh, Kaneo</creator><creator>Adachi, Kyoko</creator><creator>Matsuda, Satoru</creator><creator>Shizuri, Yoshikazu</creator><creator>Yasumoto, Ko</creator><creator>Kusumi, Takenori</creator><creator>Okumura, Kayo</creator><creator>Kirikae, Teruo</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>F1W</scope><scope>FR3</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>New Sulfoalkylresorcinol from Marine-derived Fungus, Zygosporium sp. KNC52</title><author>Kanoh, Kaneo ; Adachi, Kyoko ; Matsuda, Satoru ; Shizuri, Yoshikazu ; Yasumoto, Ko ; Kusumi, Takenori ; Okumura, Kayo ; Kirikae, Teruo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-da9dbebd5f55924d09b87e28825760b4c1249b7febdc8883fe486df30c3ffb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Bacteria - drug effects</topic><topic>Bacterial Proteins - chemistry</topic><topic>Bacteriology</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Cytoskeletal Proteins - chemistry</topic><topic>Fungi - chemistry</topic><topic>Fungi - metabolism</topic><topic>Indicators and Reagents</topic><topic>Life Sciences</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medicinal Chemistry</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology</topic><topic>Molecular Conformation</topic><topic>Organic Chemistry</topic><topic>Resorcinols - 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1
) was isolated from the marine-derived fungus,
Zygosporium
sp. KNC52. The structure of
1
was elucidated by spectroscopic methods including MS and NMR, and the absolute stereochemistry was determined by the modified Mosher's method. Compound
1
inhibited FtsZ polymerization
in vitro
and exhibited weak antimicrobial activity against multi-drugresistant bacteria.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18503198</pmid><doi>10.1038/ja.2008.29</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of antibiotics, 2008-03, Vol.61 (3), p.192-194 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Bacteria - drug effects Bacterial Proteins - chemistry Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Cytoskeletal Proteins - chemistry Fungi - chemistry Fungi - metabolism Indicators and Reagents Life Sciences Magnetic Resonance Spectroscopy Medicinal Chemistry Microbial Sensitivity Tests Microbiology Molecular Conformation Organic Chemistry Resorcinols - chemistry Spectrometry, Mass, Fast Atom Bombardment |
| title | New Sulfoalkylresorcinol from Marine-derived Fungus, Zygosporium sp. KNC52 |
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