New Sulfoalkylresorcinol from Marine-derived Fungus, Zygosporium sp. KNC52

New Sulfoalkylresorcinol from Marine-derived Fungus, Zygosporium sp. KNC52

A new sulfoalkylresorcinol ( 1 ) was isolated from the marine-derived fungus, Zygosporium sp. KNC52. The structure of 1 was elucidated by spectroscopic methods including MS and NMR, and the absolute stereochemistry was determined by the modified Mosher's method. Compound 1 inhibited FtsZ polyme...

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Veröffentlicht in:Journal of antibiotics 2008-03, Vol.61 (3), p.192-194
Hauptverfasser: Kanoh, Kaneo, Adachi, Kyoko, Matsuda, Satoru, Shizuri, Yoshikazu, Yasumoto, Ko, Kusumi, Takenori, Okumura, Kayo, Kirikae, Teruo
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria - drug effects
Bacterial Proteins - chemistry
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Cytoskeletal Proteins - chemistry
Fungi - chemistry
Fungi - metabolism
Indicators and Reagents
Life Sciences
Magnetic Resonance Spectroscopy
Medicinal Chemistry
Microbial Sensitivity Tests
Microbiology
Molecular Conformation
Organic Chemistry
Resorcinols - chemistry
Spectrometry, Mass, Fast Atom Bombardment
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Zusammenfassung:A new sulfoalkylresorcinol ( 1 ) was isolated from the marine-derived fungus, Zygosporium sp. KNC52. The structure of 1 was elucidated by spectroscopic methods including MS and NMR, and the absolute stereochemistry was determined by the modified Mosher's method. Compound 1 inhibited FtsZ polymerization in vitro and exhibited weak antimicrobial activity against multi-drugresistant bacteria.
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2008.29