Highly Stereoselective Hydrogen-Bond-Mediated Michael-Michael Cascade Process through Dynamic Kinetic Resolution

Highly Stereoselective Hydrogen-Bond-Mediated Michael-Michael Cascade Process through Dynamic Kinetic Resolution

Oh Mickey, you're so fine: The title reaction, which is efficiently catalyzed by a cinchona alkaloid thioure affords direct access to thiochromanes in high efficiency. The reaction features a new activation mode of organocatalytic dynamic kinetic resolution involving a Michael–retro‐Michael–Mic...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie (International ed.) 2008-05, Vol.47 (22), p.4177-4179
Hauptverfasser: Wang, Jian, Xie, Hexin, Li, Hao, Zu, Liansuo, Wang, Wei
Format: Artikel
Sprache:eng
Schlagworte:
cascade reactions
kinetic dynamic resolution
Michael addition
organocatalysis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Oh Mickey, you're so fine: The title reaction, which is efficiently catalyzed by a cinchona alkaloid thioure affords direct access to thiochromanes in high efficiency. The reaction features a new activation mode of organocatalytic dynamic kinetic resolution involving a Michael–retro‐Michael–Michael–Michael cascade.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200800381