Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Tagu...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2008-05, Vol.320 (5879), p.1012; author reply 1012-1012
Hauptverfasser:	Selman, Colin, Lingard, Steven, Gems, David, Partridge, Linda, Withers, Dominic J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Crosses, Genetic Diet Female Homeostasis Insulin Receptor Substrate Proteins Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kaplan-Meier Estimate Longevity Male Mice Mice, Inbred C57BL Mutation Phosphoproteins - genetics Phosphoproteins - metabolism Research Design Signal Transduction
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Beschreibung
Zusammenfassung:	Taguchi et al. (Reports, 20 July 2007, p. 369) reported that mice heterozygous for a null mutation in insulin receptor substrate-2 (Irs2) display a 17% increase in median life span. However, using the same mouse model, we find no evidence for life-span extension and suggest that the findings of Taguchi et al. were due to atypical life-span profiles in their study animals.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1152366